1d8v: Difference between revisions

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[[Image:1d8v.jpg|left|200px]]
{{Seed}}
[[Image:1d8v.png|left|200px]]


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{{STRUCTURE_1d8v|  PDB=1d8v  |  SCENE=  }}  
{{STRUCTURE_1d8v|  PDB=1d8v  |  SCENE=  }}  


'''THE RESTRAINED AND MINIMIZED AVERAGE NMR STRUCTURE OF MAP30.'''
===THE RESTRAINED AND MINIMIZED AVERAGE NMR STRUCTURE OF MAP30.===




==Overview==
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We present the solution structure of MAP30, a plant protein with anti-HIV and anti-tumor activities. Structural analysis and subsequent biochemical assays lead to several novel discoveries. First, MAP30 acts like a DNA glycosylase/apurinic (ap) lyase, an additional activity distinct from its known RNA N-glycosidase activity toward the 28S rRNA. Glycosylase/ap lyase activity explains MAP30's apparent inhibition of the HIV-1 integrase, MAP30's ability to irreversibly relax supercoiled DNA, and may be an alternative cytotoxic pathway that contributes to MAP30's anti-HIV/anti-tumor activities. Second, two distinct, but contiguous, subsites are responsible for MAP30's glycosylase/ap lyase activity. Third, Mn2+ and Zn2+ interact with negatively charged surfaces next to the catalytic sites, facilitating DNA substrate binding instead of directly participating in catalysis.
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{{ABSTRACT_PUBMED_10571185}}


==About this Structure==
==About this Structure==
1D8V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8V OCA].  
1D8V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8V OCA].  


==Reference==
==Reference==
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[[Category: Wang, Y X.]]
[[Category: Wang, Y X.]]
[[Category: Single chain]]
[[Category: Single chain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:34:47 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:41:05 2008''

Revision as of 19:41, 30 June 2008

File:1d8v.png

Template:STRUCTURE 1d8v

THE RESTRAINED AND MINIMIZED AVERAGE NMR STRUCTURE OF MAP30.

Template:ABSTRACT PUBMED 10571185

About this Structure

1D8V is a Single protein structure of sequence from Momordica charantia. Full experimental information is available from OCA.

Reference

Solution structure of anti-HIV-1 and anti-tumor protein MAP30: structural insights into its multiple functions., Wang YX, Neamati N, Jacob J, Palmer I, Stahl SJ, Kaufman JD, Huang PL, Huang PL, Winslow HE, Pommier Y, Wingfield PT, Lee-Huang S, Bax A, Torchia DA, Cell. 1999 Nov 12;99(4):433-42. PMID:10571185

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