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| {{STRUCTURE_1dab| PDB=1dab | SCENE= }} | | {{STRUCTURE_1dab| PDB=1dab | SCENE= }} |
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| '''The Structure of Bordetella Pertussis Virulence Factor P.69 Pertactin'''
| | ===The Structure of Bordetella Pertussis Virulence Factor P.69 Pertactin=== |
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| ==Overview==
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| A new generation of whooping-cough vaccines contain P.69 pertactin, a surface-exposed domain of an outer membrane protein expressed by the virulent bacterium Bordetella pertussis. This protein is a virulence factor that mediates adhesion to target mammalian cells, a reaction that is in part mediated by an RGD sequence. The X-ray crystal structure of P.69 pertactin has been determined to 2.5 A. The protein fold consists of a 16-stranded parallel beta-helix with a V-shaped cross-section, and is the largest beta-helix known to date. Several between-strand weakly conserved amino-acid repeats form internal and external ladders. The structure appears as a helix from which several loops protrude, which contain sequence motifs associated with the biological activity of the protein. One particular (GGXXP)5 sequence is located directly after the RGD motif, and may mediate interaction with epithelial cells. The carboxy-terminal region of P.69 pertactin incorporates a (PQP)5 motif loop containing the major immunoprotective epitope.
| | The line below this paragraph, {{ABSTRACT_PUBMED_8609998}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 8609998 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_8609998}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Isaacs, N W.]] | | [[Category: Isaacs, N W.]] |
| [[Category: Pertussis beta helix]] | | [[Category: Pertussis beta helix]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:37:27 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:44:13 2008'' |
