1dct: Difference between revisions

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[[Image:1dct.gif|left|200px]]
{{Seed}}
[[Image:1dct.png|left|200px]]


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{{STRUCTURE_1dct|  PDB=1dct  |  SCENE=  }}  
{{STRUCTURE_1dct|  PDB=1dct  |  SCENE=  }}  


'''DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA'''
===DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA===




==Overview==
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Many organisms expand the information content of their genome through enzymatic methylation of cytosine residues. Here we report the 2.8 A crystal structure of a bacterial DNA (cytosine-5)-methyltransferase (DCMtase), M. HaeIII, bound covalently to DNA. In this complex, the substrate cytosine is extruded from the DNA helix and inserted into the active site of the enzyme, as has been observed for another DCMtase, M. HhaI. The DNA is bound in a cleft between the two domains of the protein and is distorted from the characteristic B-form conformation at its recognition sequence. A comparison of structures shows a variation in the mode of DNA recognition: M. HaeIII differs from M. HhaI in that the remaining bases in its recognition sequence undergo an extensive rearrangement in their pairing. In this process, the bases are unstacked, and a gap 8 A long opens in the DNA.
The line below this paragraph, {{ABSTRACT_PUBMED_7606780}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_7606780}}


==About this Structure==
==About this Structure==
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[[Category: Cytosine methylase]]
[[Category: Cytosine methylase]]
[[Category: Enzyme]]
[[Category: Enzyme]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:42:13 2008''
 
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Revision as of 19:50, 30 June 2008

File:1dct.png

Template:STRUCTURE 1dct

DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA

Template:ABSTRACT PUBMED 7606780

About this Structure

1DCT is a Single protein structure of sequence from Haemophilus aegyptius. Full crystallographic information is available from OCA.

Reference

The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing., Reinisch KM, Chen L, Verdine GL, Lipscomb WN, Cell. 1995 Jul 14;82(1):143-53. PMID:7606780

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