1ddw: Difference between revisions

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[[Image:1ddw.~~gif~~|left|200px]]

[[Image:1ddw.png|left|200px]]

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~~'''~~HOMER EVH1 DOMAIN UNLIGANDED~~'''~~

===HOMER EVH1 DOMAIN UNLIGANDED===

~~==Overview==~~

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~~Homer EVH1 (Ena/VASP Homology 1) domains interact with proline~~-~~rich motifs in the cytoplasmic regions of group 1 metabotropic glutamate receptors (mGluRs), inositol~~-1,4,~~5-trisphosphate receptors (IP3Rs), and Shank proteins. We have determined~~ the ~~crystal structure of~~ the ~~Homer EVH1 domain complexed with a peptide from mGluR~~ (~~TPPSPF~~)~~. In contrast to other EVH1 domains~~, the ~~bound mGluR ligand assumes an unusual conformation in which the side chains of the Ser-Pro tandem are oriented away from the Homer surface, and the Phe forms a unique contact~~. ~~This unusual binding mode rationalizes conserved features of both Homer and Homer ligands that are not shared by other EVH1 domains. Site~~-~~directed mutagenesis confirms the importance of specific Homer residues for ligand binding. These results establish a molecular basis for understanding the biological properties of Homer~~-~~ligand complexes.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10798399}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10798399 is the PubMed ID number.

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==About this Structure==

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[[Category: Xiao, B.]]

[[Category: Pleckstrin homology domain fold]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:44:30 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:52:45 2008''

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-[[Image:1ddw.gif|left|200px]]
+{{Seed}}
+[[Image:1ddw.png|left|200px]]
 <!--
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 {{STRUCTURE_1ddw|  PDB=1ddw  |  SCENE=  }}
-'''HOMER EVH1 DOMAIN UNLIGANDED'''
+===HOMER EVH1 DOMAIN UNLIGANDED===
-==Overview==
+<!--
-Homer EVH1 (Ena/VASP Homology 1) domains interact with proline-rich motifs in the cytoplasmic regions of group 1 metabotropic glutamate receptors (mGluRs), inositol-1,4,5-trisphosphate receptors (IP3Rs), and Shank proteins. We have determined the crystal structure of the Homer EVH1 domain complexed with a peptide from mGluR (TPPSPF). In contrast to other EVH1 domains, the bound mGluR ligand assumes an unusual conformation in which the side chains of the Ser-Pro tandem are oriented away from the Homer surface, and the Phe forms a unique contact. This unusual binding mode rationalizes conserved features of both Homer and Homer ligands that are not shared by other EVH1 domains. Site-directed mutagenesis confirms the importance of specific Homer residues for ligand binding. These results establish a molecular basis for understanding the biological properties of Homer-ligand complexes.
+The line below this paragraph, {{ABSTRACT_PUBMED_10798399}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10798399 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10798399}}
 ==About this Structure==
@@ Line 28: / Line 32: @@
 [[Category: Xiao, B.]]
 [[Category: Pleckstrin homology domain fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:44:30 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:52:45 2008''