1dev: Difference between revisions

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[[Image:1dev.~~gif~~|left|200px]]

[[Image:1dev.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF SMAD2 MH2 DOMAIN BOUND TO THE SMAD-BINDING DOMAIN OF SARA~~'''~~

===CRYSTAL STRUCTURE OF SMAD2 MH2 DOMAIN BOUND TO THE SMAD-BINDING DOMAIN OF SARA===

~~==Overview==~~

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The ~~Smad proteins mediate transforming growth factor-beta (TGFbeta) signaling from~~ the ~~transmembrane serine-threonine receptor kinases~~ to the ~~nucleus. The Smad anchor for receptor activation (SARA) recruits Smad2 to the TGFbeta receptors for phosphorylation. The crystal structure of a Smad2 MH2 domain in complex with the Smad-binding domain~~ (~~SBD) of SARA has been determined~~ at 2.~~2 angstrom resolution~~. ~~SARA SBD~~, ~~in an extended conformation comprising a rigid coil, an alpha helix, and a beta strand, interacts with the beta sheet and~~ the ~~three-helix bundle of Smad2~~. ~~Recognition between the SARA rigid coil and the Smad2 beta sheet is essential for specificity, whereas interactions between the SARA beta strand and the Smad2 three~~-~~helix bundle contribute significantly to binding affinity. Comparison of the structures between Smad2 and a comediator Smad suggests a model for how receptor~~-~~regulated Smads are recognized by the type I receptors.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10615055}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10615055 is the PubMed ID number.

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==About this Structure==

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[[Category: Beta sheet]]

[[Category: Three-helix bundle]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:46:29 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:55:08 2008''

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-[[Image:1dev.gif|left|200px]]
+{{Seed}}
+[[Image:1dev.png|left|200px]]
 <!--
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 {{STRUCTURE_1dev|  PDB=1dev  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF SMAD2 MH2 DOMAIN BOUND TO THE SMAD-BINDING DOMAIN OF SARA'''
+===CRYSTAL STRUCTURE OF SMAD2 MH2 DOMAIN BOUND TO THE SMAD-BINDING DOMAIN OF SARA===
-==Overview==
+<!--
-The Smad proteins mediate transforming growth factor-beta (TGFbeta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus. The Smad anchor for receptor activation (SARA) recruits Smad2 to the TGFbeta receptors for phosphorylation. The crystal structure of a Smad2 MH2 domain in complex with the Smad-binding domain (SBD) of SARA has been determined at 2.2 angstrom resolution. SARA SBD, in an extended conformation comprising a rigid coil, an alpha helix, and a beta strand, interacts with the beta sheet and the three-helix bundle of Smad2. Recognition between the SARA rigid coil and the Smad2 beta sheet is essential for specificity, whereas interactions between the SARA beta strand and the Smad2 three-helix bundle contribute significantly to binding affinity. Comparison of the structures between Smad2 and a comediator Smad suggests a model for how receptor-regulated Smads are recognized by the type I receptors.
+The line below this paragraph, {{ABSTRACT_PUBMED_10615055}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10615055 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10615055}}
 ==About this Structure==
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 [[Category: Beta sheet]]
 [[Category: Three-helix bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:46:29 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:55:08 2008''