1dk8: Difference between revisions

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[[Image:1dk8.jpg|left|200px]]
{{Seed}}
[[Image:1dk8.png|left|200px]]


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{{STRUCTURE_1dk8|  PDB=1dk8  |  SCENE=  }}  
{{STRUCTURE_1dk8|  PDB=1dk8  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN'''
===CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN===




==Overview==
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Axin and the adenomatous polyposis coli (APC) tumor suppressor protein are components of the Wnt/Wingless growth factor signaling pathway. In the absence of Wnt signal, Axin and APC regulate cytoplasmic levels of the proto-oncogene beta-catenin through the formation of a large complex containing these three proteins, glycogen synthase kinase 3beta (GSK3beta) and several other proteins. Both Axin and APC are known to be critical for beta-catenin regulation, and truncations in APC that eliminate the Axin-binding site result in human cancers. A protease-resistant domain of Axin that contains the APC-binding site is a member of the regulators of G-protein signaling (RGS) superfamily. The crystal structures of this domain alone and in complex with an Axin-binding sequence from APC reveal that the Axin-APC interaction occurs at a conserved groove on a face of the protein that is distinct from the G-protein interface of classical RGS proteins. The molecular interactions observed in the Axin-APC complex provide a rationale for the evolutionary conservation seen in both proteins.
The line below this paragraph, {{ABSTRACT_PUBMED_10811618}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10811618 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10811618}}


==About this Structure==
==About this Structure==
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[[Category: Alpha-helix]]
[[Category: Alpha-helix]]
[[Category: Pi-helix]]
[[Category: Pi-helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:56:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:11:40 2008''

Revision as of 20:11, 30 June 2008

File:1dk8.png

Template:STRUCTURE 1dk8

CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN

Template:ABSTRACT PUBMED 10811618

About this Structure

1DK8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of the Axin-adenomatous polyposis coli interaction., Spink KE, Polakis P, Weis WI, EMBO J. 2000 May 15;19(10):2270-9. PMID:10811618

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