1dm0: Difference between revisions

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[[Image:1dm0.gif|left|200px]]
{{Seed}}
[[Image:1dm0.png|left|200px]]


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{{STRUCTURE_1dm0|  PDB=1dm0  |  SCENE=  }}  
{{STRUCTURE_1dm0|  PDB=1dm0  |  SCENE=  }}  


'''SHIGA TOXIN'''
===SHIGA TOXIN===




==Overview==
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Shigella dysenteriae is the pathogen responsible for the severe form of dysentery in humans. It produces Shiga toxin, the prototype of a family of closely related bacterial protein toxins. We have determined the structure of the holotoxin, an AB5 hexamer, by X-ray crystallography. The five B subunits form a pentameric ring, encircling a helix at the carboxy terminus of the A subunit. The A subunit interacts with the B pentamer via this C-terminal helix and a four-stranded mixed beta-sheet. The fold of the rest of the A subunit is similar to that of the A chain of the plant toxin ricin; both are N-glycosidases. However, the active site in the bacterial holotoxin is blocked by a segment of polypeptide chain. These residues of the A subunit would be released as part of the activation mechanism of the toxin.
The line below this paragraph, {{ABSTRACT_PUBMED_7656009}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_7656009}}


==About this Structure==
==About this Structure==
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[[Category: Blocking]]
[[Category: Blocking]]
[[Category: Polypeptide some]]
[[Category: Polypeptide some]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:00:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:16:31 2008''

Revision as of 20:16, 30 June 2008

File:1dm0.png

Template:STRUCTURE 1dm0

SHIGA TOXIN

Template:ABSTRACT PUBMED 7656009

About this Structure

1DM0 is a Protein complex structure of sequences from Shigella dysenteriae. Full crystallographic information is available from OCA.

Reference

Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution., Fraser ME, Chernaia MM, Kozlov YV, James MN, Nat Struct Biol. 1994 Jan;1(1):59-64. PMID:7656009

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