1dow: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1dow.gif|left|200px]]
{{Seed}}
[[Image:1dow.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1dow|  PDB=1dow  |  SCENE=  }}  
{{STRUCTURE_1dow|  PDB=1dow  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF A CHIMERA OF BETA-CATENIN AND ALPHA-CATENIN'''
===CRYSTAL STRUCTURE OF A CHIMERA OF BETA-CATENIN AND ALPHA-CATENIN===




==Overview==
<!--  
In adherens junctions, alpha-catenin links the cadherin-beta-catenin complex to the actin-based cytoskeleton. alpha-catenin is a homodimer in solution, but forms a 1:1 heterodimer with beta-catenin. The crystal structure of the alpha-catenin dimerization domain, residues 82-279, shows that alpha-catenin dimerizes through formation of a four-helix bundle in which two antiparallel helices are contributed by each protomer. A slightly larger fragment, comprising residues 57-264, binds to beta-catenin. A chimera consisting of the alpha-catenin-binding region of beta-catenin linked to the amino terminus of alpha-catenin 57-264 behaves as a monomer in solution, as expected, since beta-catenin binding disrupts the alpha-catenin dimer. The crystal structure of this chimera reveals the interaction between alpha- and beta-catenin, and provides a basis for understanding adherens junction assembly.
The line below this paragraph, {{ABSTRACT_PUBMED_10882138}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10882138 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10882138}}


==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
[[Category: Four-helix bundle]]
[[Category: Four-helix bundle]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:05:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:23:47 2008''
Retrieved from "https://proteopedia.org/1dow"