1dqo: Difference between revisions

Line 1:

[[Image:1dqo.~~gif~~|left|200px]]

[[Image:1dqo.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~CRYSTAL STRUCTURE OF THE CYSTEINE RICH DOMAIN OF MANNOSE RECEPTOR COMPLEXED WITH ACETYLGALACTOSAMINE-4-SULFATE~~'''~~

===CRYSTAL STRUCTURE OF THE CYSTEINE RICH DOMAIN OF MANNOSE RECEPTOR COMPLEXED WITH ACETYLGALACTOSAMINE-4-SULFATE===

~~==Overview==~~

<!--

The macrophage and epithelial cell mannose receptor (MR) binds carbohydrates on foreign and host molecules. Two portions of MR recognize carbohydrates: tandemly arranged C-type lectin domains facilitate carbohydrate-dependent macrophage uptake of infectious organisms, ~~and~~ the ~~NH(2)-terminal cysteine-rich domain (Cys-MR) binds~~ to ~~sulfated glycoproteins including pituitary hormones. To elucidate~~ the ~~mechanism of sulfated carbohydrate recognition, we determined crystal structures of Cys-MR alone and complexed with 4-sulfated-N-acetylgalactosamine~~ at 1.~~7 and 2~~.~~2 A resolution~~, respectively. Cys-MR folds into an approximately three-fold symmetric beta-trefoil shape resembling fibroblast growth factor. The sulfate portions of 4-sulfated-N-acetylgalactosamine and an unidentified ligand found in the native crystals bind in a neutral pocket in the ~~third lobe~~. ~~We use the structures to rationalize the carbohydrate binding specificities of Cys~~-~~MR and compare the recognition properties of Cys~~-~~MR with other beta-trefoil proteins.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10748229}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10748229 is the PubMed ID number.

-->

==About this Structure==

Line 33:

Line 37:

[[Category: Pituitary hormone]]

[[Category: Sulfated carbohydrate]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 14~~:09:44 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:28:27 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1dqo.gif|left|200px]]
+{{Seed}}
+[[Image:1dqo.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1dqo|  PDB=1dqo  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE CYSTEINE RICH DOMAIN OF MANNOSE RECEPTOR COMPLEXED WITH ACETYLGALACTOSAMINE-4-SULFATE'''
+===CRYSTAL STRUCTURE OF THE CYSTEINE RICH DOMAIN OF MANNOSE RECEPTOR COMPLEXED WITH ACETYLGALACTOSAMINE-4-SULFATE===
-==Overview==
+<!--
-The macrophage and epithelial cell mannose receptor (MR) binds carbohydrates on foreign and host molecules. Two portions of MR recognize carbohydrates: tandemly arranged C-type lectin domains facilitate carbohydrate-dependent macrophage uptake of infectious organisms, and the NH(2)-terminal cysteine-rich domain (Cys-MR) binds to sulfated glycoproteins including pituitary hormones. To elucidate the mechanism of sulfated carbohydrate recognition, we determined crystal structures of Cys-MR alone and complexed with 4-sulfated-N-acetylgalactosamine at 1.7 and 2.2 A resolution, respectively. Cys-MR folds into an approximately three-fold symmetric beta-trefoil shape resembling fibroblast growth factor. The sulfate portions of 4-sulfated-N-acetylgalactosamine and an unidentified ligand found in the native crystals bind in a neutral pocket in the third lobe. We use the structures to rationalize the carbohydrate binding specificities of Cys-MR and compare the recognition properties of Cys-MR with other beta-trefoil proteins.
+The line below this paragraph, {{ABSTRACT_PUBMED_10748229}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10748229 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10748229}}
 ==About this Structure==
@@ Line 33: / Line 37: @@
 [[Category: Pituitary hormone]]
 [[Category: Sulfated carbohydrate]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:09:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:28:27 2008''