1dsm: Difference between revisions

Line 1:

[[Image:1dsm.~~gif~~|left|200px]]

[[Image:1dsm.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~(-)-duocarmycin SA covalently linked to duplex DNA~~'''~~

===(-)-duocarmycin SA covalently linked to duplex DNA===

~~==Overview==~~

<!--

~~Duocarmycin SA is a member of a growing class of interesting lead compounds for chemotherapy~~, ~~distinguished by~~ the ~~manner in which they bind~~ to ~~and react with DNA substrates. The first three-dimensional structure of a DNA adduct of an unnatural enantiomer from this family has been determined by~~ (~~1)H NMR methods~~. Comparison to the previously determined structure of the natural enantiomer bound in the same DNA-binding site provides unique insights into the similarities and critical distinctions producing the respective alkylation products and site selectivities. ~~The results also support the hypothesis that the duocarmycin SA alkylation reaction~~ is ~~catalyzed by the binding to DNA, and provide a deeper understanding of~~ the ~~structural basis for this unique mode of activation~~.

The line below this paragraph, {{ABSTRACT_PUBMED_10903864}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10903864 is the PubMed ID number.

-->

==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DSM OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DSM OCA].

==Reference==

Line 28:

Line 32:

[[Category: Duocarmycin]]

[[Category: Minor groove binding]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 14~~:13:32 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:33:17 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1dsm.gif|left|200px]]
+{{Seed}}
+[[Image:1dsm.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1dsm|  PDB=1dsm  |  SCENE=  }}
-'''(-)-duocarmycin SA covalently linked to duplex DNA'''
+===(-)-duocarmycin SA covalently linked to duplex DNA===
-==Overview==
+<!--
-Duocarmycin SA is a member of a growing class of interesting lead compounds for chemotherapy, distinguished by the manner in which they bind to and react with DNA substrates. The first three-dimensional structure of a DNA adduct of an unnatural enantiomer from this family has been determined by (1)H NMR methods. Comparison to the previously determined structure of the natural enantiomer bound in the same DNA-binding site provides unique insights into the similarities and critical distinctions producing the respective alkylation products and site selectivities. The results also support the hypothesis that the duocarmycin SA alkylation reaction is catalyzed by the binding to DNA, and provide a deeper understanding of the structural basis for this unique mode of activation.
+The line below this paragraph, {{ABSTRACT_PUBMED_10903864}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10903864 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10903864}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DSM OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DSM OCA].
 ==Reference==
@@ Line 28: / Line 32: @@
 [[Category: Duocarmycin]]
 [[Category: Minor groove binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:13:32 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:33:17 2008''