1dtv: Difference between revisions

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[[Image:1dtv.jpg|left|200px]]
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[[Image:1dtv.png|left|200px]]


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{{STRUCTURE_1dtv|  PDB=1dtv  |  SCENE=  }}  
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'''NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI)'''
===NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI)===




==Overview==
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Leech carboxypeptidase inhibitor (LCI) is a novel protein inhibitor present in the medicinal leech Hirudo medicinalis. The structures of LCI free and bound to carboxypeptidase A2 (CPA2)have been determined by NMR and X-ray crystallography, respectively. The LCI structure defines a new protein motif that comprises a five-stranded antiparallel beta-sheet and one short alpha-helix. This structure is preserved in the complex with human CPA2 in the X-ray structure, where the contact regions between the inhibitor and the protease are defined. The C-terminal tail of LCI becomes rigid upon binding the protease as shown in the NMR relaxation studies, and it interacts with the carboxypeptidase in a substrate-like manner. The homology between the C-terminal tails of LCI and the potato carboxypeptidase inhibitor represents a striking example of convergent evolution dictated by the target protease. These new structures are of biotechnological interest since they could elucidate the control mechanism of metallo-carboxypeptidases and could be used as lead compounds for the search of fibrinolytic drugs.
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==About this Structure==
==About this Structure==
1DTV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DTV OCA].  
1DTV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DTV OCA].  


==Reference==
==Reference==
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[[Category: Lci]]
[[Category: Lci]]
[[Category: Leech carboxypeptidase inhibitor]]
[[Category: Leech carboxypeptidase inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:16:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:36:28 2008''

Revision as of 20:36, 30 June 2008

File:1dtv.png

Template:STRUCTURE 1dtv

NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI)

Template:ABSTRACT PUBMED 10742178

About this Structure

1DTV is a Single protein structure of sequence from Hirudo medicinalis. Full experimental information is available from OCA.

Reference

Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2., Reverter D, Fernandez-Catalan C, Baumgartner R, Pfander R, Huber R, Bode W, Vendrell J, Holak TA, Aviles FX, Nat Struct Biol. 2000 Apr;7(4):322-8. PMID:10742178

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