1dud: Difference between revisions

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[[Image:1dud.~~gif~~|left|200px]]

[[Image:1dud.png|left|200px]]

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~~'''~~DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE (D-UTPASE) COMPLEXED WITH THE SUBSTRATE ANALOGUE DEOXYURIDINE 5'-DIPHOSPHATE (D-UDP)~~'''~~

===DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE (D-UTPASE) COMPLEXED WITH THE SUBSTRATE ANALOGUE DEOXYURIDINE 5'-DIPHOSPHATE (D-UDP)===

~~==Overview==~~

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~~We have determined the structure of the homotrimeric dUTPase from Escherichia coli~~, ~~completed with an inhibitor and substrate analogue~~, ~~dUDP. Three molecules of dUDP are found symmetrically bound per trimer, each in a shallow cleft between adjacent subunits, interacting with evolutionary conserved residues. The interactions of~~ the ~~uracil ring and~~ the ~~deoxypentose with the protein are consistent with the high specificity of the enzyme with respect to these groups~~. ~~The positions of the two phosphate groups and adjacent water molecules are discussed in relation to the mechanism and kinetics of catalysis~~. ~~The role that dUTPase plays in DNA metabolism makes the enzyme a potential target for chemotherapeutic drugs: the results presented here will aid in~~ the ~~design and development of inhibitory compounds~~.

The line below this paragraph, {{ABSTRACT_PUBMED_8646539}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8646539 is the PubMed ID number.

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==About this Structure==

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[[Category: Nucleotide metabolism]]

[[Category: Substrate analogue]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 14~~:17:06 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:37:47 2008''

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-[[Image:1dud.gif|left|200px]]
+{{Seed}}
+[[Image:1dud.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1dud|  PDB=1dud  |  SCENE=  }}
-'''DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE (D-UTPASE) COMPLEXED WITH THE SUBSTRATE ANALOGUE DEOXYURIDINE 5'-DIPHOSPHATE (D-UDP)'''
+===DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE (D-UTPASE) COMPLEXED WITH THE SUBSTRATE ANALOGUE DEOXYURIDINE 5'-DIPHOSPHATE (D-UDP)===
-==Overview==
+<!--
-We have determined the structure of the homotrimeric dUTPase from Escherichia coli, completed with an inhibitor and substrate analogue, dUDP. Three molecules of dUDP are found symmetrically bound per trimer, each in a shallow cleft between adjacent subunits, interacting with evolutionary conserved residues. The interactions of the uracil ring and the deoxypentose with the protein are consistent with the high specificity of the enzyme with respect to these groups. The positions of the two phosphate groups and adjacent water molecules are discussed in relation to the mechanism and kinetics of catalysis. The role that dUTPase plays in DNA metabolism makes the enzyme a potential target for chemotherapeutic drugs: the results presented here will aid in the design and development of inhibitory compounds.
+The line below this paragraph, {{ABSTRACT_PUBMED_8646539}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8646539 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8646539}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Nucleotide metabolism]]
 [[Category: Substrate analogue]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:17:06 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:37:47 2008''