1duy: Difference between revisions

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[[Image:1duy.jpg|left|200px]]
{{Seed}}
[[Image:1duy.png|left|200px]]


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{{STRUCTURE_1duy|  PDB=1duy  |  SCENE=  }}  
{{STRUCTURE_1duy|  PDB=1duy  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HLA-A*0201/OCTAMERIC TAX PEPTIDE COMPLEX'''
===CRYSTAL STRUCTURE OF HLA-A*0201/OCTAMERIC TAX PEPTIDE COMPLEX===




==Overview==
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The crystal structure of the human class I MHC molecule HLA-A2 complexed with of an octameric peptide, Tax8 (LFGYPVYV), from human T cell lymphotrophic virus-1 (HTLV-1) has been determined. This structure is compared with a newly refined, higher resolution (1.8 A) structure of HLA-A2 complexed with the nonameric Tax9 peptide (LLFGYPVYV) with one more N-terminal residue. Despite the absence of a peptide residue (P1) bound in the conserved N-terminal peptide-binding pocket of the Tax8/HLA-A2 complex, the structures of the two complexes are essentially identical. Water molecules in the Tax8 complex replace the terminal amino group of the Tax9 peptide and mediate a network of hydrogen bonds among the secondary structural elements at that end of the peptide-binding groove. Thermal denaturation measurements indicate that the Tax8 complex is much less stable, DeltaTm = 16 degrees C, than the Tax9 complex, but both can sensitize target cells for lysis by some Tax-specific CTL from HTLV-1 infected individuals. The absence of a P1 peptide residue is thus not enough to prevent formation of a "closed conformation" of the peptide-binding site. TCR affinity measurements and cytotoxic T cell assays indicate that the Tax8/HLA-A2 complex does not functionally cross-react with the A6-TCR-bearing T cell clone specific for Tax9/HLA-A2 complexes.
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{{ABSTRACT_PUBMED_10843695}}


==About this Structure==
==About this Structure==
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[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:18:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:39:31 2008''

Revision as of 20:39, 30 June 2008

File:1duy.png

Template:STRUCTURE 1duy

CRYSTAL STRUCTURE OF HLA-A*0201/OCTAMERIC TAX PEPTIDE COMPLEX

Template:ABSTRACT PUBMED 10843695

About this Structure

1DUY is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure and stability of an HLA-A*0201/octameric tax peptide complex with an empty conserved peptide-N-terminal binding site., Khan AR, Baker BM, Ghosh P, Biddison WE, Wiley DC, J Immunol. 2000 Jun 15;164(12):6398-405. PMID:10843695

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