1dvi: Difference between revisions

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[[Image:1dvi.gif|left|200px]]
{{Seed}}
[[Image:1dvi.png|left|200px]]


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{{STRUCTURE_1dvi|  PDB=1dvi  |  SCENE=  }}  
{{STRUCTURE_1dvi|  PDB=1dvi  |  SCENE=  }}  


'''CALPAIN DOMAIN VI WITH CALCIUM BOUND'''
===CALPAIN DOMAIN VI WITH CALCIUM BOUND===




==Overview==
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The crystal structure of a Ca(2+)-binding domain (dVI) of rat m-calpain has been determined at 2.3 A resolution, both with and without bound Ca2+. The structures reveal a unique fold incorporating five EF-hand motifs per monomer, three of which bind calcium at physiological calcium concentrations, with one showing a novel EF-hand coordination pattern. This investigation gives us a first view of the calcium-induced conformational changes, and consequently an insight into the mechanism of calcium induced activation in calpain. The crystal structures reveal a dVI homodimer which provides a preliminary model for the subunit dimerization in calpain.
The line below this paragraph, {{ABSTRACT_PUBMED_9228945}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9228945 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9228945}}


==About this Structure==
==About this Structure==
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[[Category: Calcium-dependent protease]]
[[Category: Calcium-dependent protease]]
[[Category: Small subunit]]
[[Category: Small subunit]]
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