1dxe: Difference between revisions

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[[Image:1dxe.gif|left|200px]]
{{Seed}}
[[Image:1dxe.png|left|200px]]


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{{STRUCTURE_1dxe|  PDB=1dxe  |  SCENE=  }}  
{{STRUCTURE_1dxe|  PDB=1dxe  |  SCENE=  }}  


'''2-DEHYDRO-3-DEOXY-GALACTARATE ALDOLASE FROM ESCHERICHIA COLI'''
===2-DEHYDRO-3-DEOXY-GALACTARATE ALDOLASE FROM ESCHERICHIA COLI===




==Overview==
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Carbon-carbon bond formation is an essential reaction in organic chemistry and the use of aldolase enzymes for the stereochemical control of such reactions is an attractive alternative to conventional chemical methods. Here we describe the crystal structures of a novel class II enzyme, 2-dehydro-3-deoxy-galactarate (DDG) aldolase from Escherichia coli, in the presence and absence of substrate. The crystal structure was determined by locating only four Se sites to obtain phases for 506 protein residues. The protomer displays a modified (alpha/beta)(8) barrel fold, in which the eighth alpha-helix points away from the beta-barrel instead of packing against it. Analysis of the DDG aldolase crystal structures suggests a novel aldolase mechanism in which a phosphate anion accepts the proton from the methyl group of pyruvate.
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{{ABSTRACT_PUBMED_10921867}}


==About this Structure==
==About this Structure==
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[[Category: Izard, T.]]
[[Category: Izard, T.]]
[[Category: Class ii aldolase]]
[[Category: Class ii aldolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:23:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:45:41 2008''

Revision as of 20:45, 30 June 2008

File:1dxe.png

Template:STRUCTURE 1dxe

2-DEHYDRO-3-DEOXY-GALACTARATE ALDOLASE FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 10921867

About this Structure

1DXE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structures of the metal-dependent 2-dehydro-3-deoxy-galactarate aldolase suggest a novel reaction mechanism., Izard T, Blackwell NC, EMBO J. 2000 Aug 1;19(15):3849-56. PMID:10921867

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