1dyq: Difference between revisions

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Bots, Bureaucrats, journal, Administrators
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[[Image:1dyq.gif|left|200px]]
{{Seed}}
[[Image:1dyq.png|left|200px]]


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{{STRUCTURE_1dyq|  PDB=1dyq  |  SCENE=  }}  
{{STRUCTURE_1dyq|  PDB=1dyq  |  SCENE=  }}  


'''STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE'''
===STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE===




==Overview==
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Staphylococcal enterotoxins (SEs) are superantigenic protein toxins responsible for a number of life-threatening diseases. The X-ray structure of a staphylococcal enterotoxin A (SEA) triple-mutant (L48R, D70R, and Y92A) vaccine reveals a cascade of structural rearrangements located in three loop regions essential for binding the alpha subunit of major histocompatibility complex class II (MHC-II) molecules. A comparison of hypothetical model complexes between SEA and the SEA triple mutant with MHC-II HLA-DR1 clearly shows disruption of key ionic and hydrophobic interactions necessary for forming the complex. Extensive dislocation of the disulfide loop in particular interferes with MHC-IIalpha binding. The triple-mutant structure provides new insights into the loss of superantigenicity and toxicity of an engineered superantigen and provides a basis for further design of enterotoxin vaccines.
The line below this paragraph, {{ABSTRACT_PUBMED_11847286}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11847286 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11847286}}


==About this Structure==
==About this Structure==
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[[Category: Staphylococcal enterotoxin type some]]
[[Category: Staphylococcal enterotoxin type some]]
[[Category: Vaccine]]
[[Category: Vaccine]]
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