1dzd: Difference between revisions

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[[Image:1dzd.gif|left|200px]]
{{Seed}}
[[Image:1dzd.png|left|200px]]


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{{STRUCTURE_1dzd|  PDB=1dzd  |  SCENE=  }}  
{{STRUCTURE_1dzd|  PDB=1dzd  |  SCENE=  }}  


'''HIGH RESOLUTION STRUCTURE OF ACIDIC FIBROBLAST GROWTH FACTOR (27-154), 24 NMR STRUCTURES'''
===HIGH RESOLUTION STRUCTURE OF ACIDIC FIBROBLAST GROWTH FACTOR (27-154), 24 NMR STRUCTURES===




==Overview==
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A shortened genetically engineered form of acidic fibroblast growth factor (aFGF), that includes amino acids 28-154 of the full-length sequence (154 residues) plus Met in substitution of Leu27, does not induce cell division even though it is recognized by the cell membrane receptor, triggers the early mitogenic events, and retains the neuromodulatory, vasoactive, and cardio- and neuroprotective properties of the native full-length molecule. Taken together, these properties make this truncated aFGF a promising compound in the treatment of a wide assortment of neurological and cardiovascular pathologies where aFGF mitogenic activity is dispensable. Differences in biological activities between the shortened aFGF and the wild-type form have been attributed to lack of stability, and to the specific amino acid sequence missing at the N-terminus. Here we show that this shortened aFGF form has a three-dimensional structure even more stable than the wild-type protein at the mitogenic assay conditions; that this structure is similar to that of the wild type except at site 1 of interaction with the cell membrane receptor; that its lack of mitogenic activity cannot be attributed to the specific missing sequence; and that the vasodilatory activity of aFGF seems impaired by alterations of the three-dimensional structure of site 2 of interaction with the cell membrane receptor.
The line below this paragraph, {{ABSTRACT_PUBMED_10819962}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10819962 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10819962}}


==About this Structure==
==About this Structure==
1DZD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZD OCA].  
1DZD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZD OCA].  


==Reference==
==Reference==
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[[Category: Fibroblast growth factor]]
[[Category: Fibroblast growth factor]]
[[Category: Growth factor]]
[[Category: Growth factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:28:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:53:04 2008''

Revision as of 20:53, 30 June 2008

File:1dzd.png

Template:STRUCTURE 1dzd

HIGH RESOLUTION STRUCTURE OF ACIDIC FIBROBLAST GROWTH FACTOR (27-154), 24 NMR STRUCTURES

Template:ABSTRACT PUBMED 10819962

About this Structure

1DZD is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

1H NMR structural characterization of a nonmitogenic, vasodilatory, ischemia-protector and neuromodulatory acidic fibroblast growth factor., Lozano RM, Pineda-Lucena A, Gonzalez C, Angeles Jimenez M, Cuevas P, Redondo-Horcajo M, Sanz JM, Rico M, Gimenez-Gallego G, Biochemistry. 2000 May 2;39(17):4982-93. PMID:10819962

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