1dzi: Difference between revisions

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[[Image:1dzi.~~gif~~|left|200px]]

[[Image:1dzi.png|left|200px]]

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~~'''~~INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX~~'''~~

===INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX===

~~==Overview==~~

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~~We have determined~~ the ~~crystal structure of a complex between~~ the ~~I domain of integrin alpha2beta1 and a triple helical collagen peptide containing a critical GFOGER motif. Three loops~~ on ~~the upper surface of the I domain that coordinate a metal ion also engage the collagen, with a collagen glutamate completing the coordination sphere of the metal~~. ~~Comparison with the unliganded I domain reveals a change in metal coordination linked to a reorganization of the upper surface that together create a complementary surface for binding collagen~~. ~~Conformational changes propagate from~~ the ~~upper surface to the opposite pole of the domain, suggesting both a basis for affinity regulation and a pathway for signal transduction~~. ~~The structural features observed here may represent a general mechanism for integrin~~-~~ligand recognition.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10778855}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10778855 is the PubMed ID number.

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==About this Structure==

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[[Category: Collagen]]

[[Category: Integrin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 14~~:28:26 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:53:31 2008''

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-[[Image:1dzi.gif|left|200px]]
+{{Seed}}
+[[Image:1dzi.png|left|200px]]
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 {{STRUCTURE_1dzi|  PDB=1dzi  |  SCENE=  }}
-'''INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX'''
+===INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX===
-==Overview==
+<!--
-We have determined the crystal structure of a complex between the I domain of integrin alpha2beta1 and a triple helical collagen peptide containing a critical GFOGER motif. Three loops on the upper surface of the I domain that coordinate a metal ion also engage the collagen, with a collagen glutamate completing the coordination sphere of the metal. Comparison with the unliganded I domain reveals a change in metal coordination linked to a reorganization of the upper surface that together create a complementary surface for binding collagen. Conformational changes propagate from the upper surface to the opposite pole of the domain, suggesting both a basis for affinity regulation and a pathway for signal transduction. The structural features observed here may represent a general mechanism for integrin-ligand recognition.
+The line below this paragraph, {{ABSTRACT_PUBMED_10778855}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10778855 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10778855}}
 ==About this Structure==
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 [[Category: Collagen]]
 [[Category: Integrin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:28:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:53:31 2008''