1e0m: Difference between revisions

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[[Image:1e0m.gif|left|200px]]
{{Seed}}
[[Image:1e0m.png|left|200px]]


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{{STRUCTURE_1e0m|  PDB=1e0m  |  SCENE=  }}  
{{STRUCTURE_1e0m|  PDB=1e0m  |  SCENE=  }}  


'''PROTOTYPE WW DOMAIN'''
===PROTOTYPE WW DOMAIN===




==Overview==
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Two new NMR structures of WW domains, the mouse formin binding protein and a putative 84.5 kDa protein from Saccharomyces cerevisiae, show that this domain, only 35 amino acids in length, defines the smallest monomeric triple-stranded antiparallel beta-sheet protein domain that is stable in the absence of disulfide bonds, tightly bound ions or ligands. The structural roles of conserved residues have been studied using site-directed mutagenesis of both wild type domains. Crucial interactions responsible for the stability of the WW structure have been identified. Based on a network of highly conserved long range interactions across the beta-sheet structure that supports the WW fold and on a systematic analysis of conserved residues in the WW family, we have designed a folded prototype WW sequence.
The line below this paragraph, {{ABSTRACT_PUBMED_10802733}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10802733 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10802733}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0M OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0M OCA].  


==Reference==
==Reference==
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[[Category: Protein design]]
[[Category: Protein design]]
[[Category: Wwprototype]]
[[Category: Wwprototype]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:30:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:56:32 2008''

Revision as of 20:56, 30 June 2008

File:1e0m.png

Template:STRUCTURE 1e0m

PROTOTYPE WW DOMAIN

Template:ABSTRACT PUBMED 10802733

About this Structure

Full experimental information is available from OCA.

Reference

Structural analysis of WW domains and design of a WW prototype., Macias MJ, Gervais V, Civera C, Oschkinat H, Nat Struct Biol. 2000 May;7(5):375-9. PMID:10802733

Page seeded by OCA on Mon Jun 30 23:56:32 2008

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