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| {{STRUCTURE_1e0r| PDB=1e0r | SCENE= }} | | {{STRUCTURE_1e0r| PDB=1e0r | SCENE= }} |
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| '''BETA-APICAL DOMAIN OF THERMOSOME'''
| | ===BETA-APICAL DOMAIN OF THERMOSOME=== |
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| ==Overview==
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| The crystal structure of the beta-apical domain of the thermosome, an archaeal group II chaperonin from Thermoplasma acidophilum, has been determined at 2.8 A resolution. The structure shows an invariant globular core from which a 25 A long protrusion emanates, composed of an elongated alpha-helix (H10) and a long extended stretch consisting of residues GluB245-ThrB253. A comparison with previous apical domain structures reveals a large segmental displacement of the protruding part of helix H10 via the hinge GluB276-ValB278. The region comprising residues GluB245-ThrB253 adopts an extended beta-like conformation rather than the alpha-helix seen in the alpha-apical domain. Consequently, it appears that the protrusions of the apical domains from group II chaperonins might assume a variety of context-dependent conformations during an open, substrate-accepting state of the chaperonin. Sequence variations in the protrusion regions that are found in the eukaryotic TRiC/CCT subunits may provide different structural propensities and hence serve different roles in substrate recognition. | | The line below this paragraph, {{ABSTRACT_PUBMED_10926489}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10926489 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_10926489}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Thermoplasma acidophilum]] | | [[Category: Thermoplasma acidophilum]] |
| [[Category: Thermosome]] | | [[Category: Thermosome]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:30:57 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:56:54 2008'' |
