1e7k: Difference between revisions

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[[Image:1e7k.~~gif~~|left|200px]]

[[Image:1e7k.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF THE SPLICEOSOMAL 15.5KD PROTEIN BOUND TO A U4 SNRNA FRAGMENT~~'''~~

===CRYSTAL STRUCTURE OF THE SPLICEOSOMAL 15.5KD PROTEIN BOUND TO A U4 SNRNA FRAGMENT===

~~==Overview==~~

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~~We have determined~~ the ~~crystal structure of a spliceosomal RNP complex comprising~~ the ~~15.5kD protein of the human U4~~/U6.~~U5 tri-snRNP and the 5' stem-loop of U4 snRNA~~. ~~The protein interacts almost exclusively with a purine-rich (5+2~~) ~~internal loop within the 5' stem-loop~~, giving an unusual RNA fold characterized by two tandem sheared G-A base pairs, a high degree of purine stacking, and the accommodation of a single RNA base, rotated out of the RNA chain, in a pocket of the ~~protein~~. ~~Apart from yielding the structure of an important entity in the pre~~-mRNA splicing apparatus, this work also implies a model for the complex of the 15.5kD protein with box C/D snoRNAs. It additionally suggests a general recognition principle in a novel family of RNA binding proteins.

The line below this paragraph, {{ABSTRACT_PUBMED_11163207}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11163207 is the PubMed ID number.

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==About this Structure==

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[[Category: Splicing]]

[[Category: U4 snrna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 14~~:45:46 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:16:59 2008''

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-[[Image:1e7k.gif|left|200px]]
+{{Seed}}
+[[Image:1e7k.png|left|200px]]
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 {{STRUCTURE_1e7k|  PDB=1e7k  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE SPLICEOSOMAL 15.5KD PROTEIN BOUND TO A U4 SNRNA FRAGMENT'''
+===CRYSTAL STRUCTURE OF THE SPLICEOSOMAL 15.5KD PROTEIN BOUND TO A U4 SNRNA FRAGMENT===
-==Overview==
+<!--
-We have determined the crystal structure of a spliceosomal RNP complex comprising the 15.5kD protein of the human U4/U6.U5 tri-snRNP and the 5' stem-loop of U4 snRNA. The protein interacts almost exclusively with a purine-rich (5+2) internal loop within the 5' stem-loop, giving an unusual RNA fold characterized by two tandem sheared G-A base pairs, a high degree of purine stacking, and the accommodation of a single RNA base, rotated out of the RNA chain, in a pocket of the protein. Apart from yielding the structure of an important entity in the pre-mRNA splicing apparatus, this work also implies a model for the complex of the 15.5kD protein with box C/D snoRNAs. It additionally suggests a general recognition principle in a novel family of RNA binding proteins.
+The line below this paragraph, {{ABSTRACT_PUBMED_11163207}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11163207 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11163207}}
 ==About this Structure==
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 [[Category: Splicing]]
 [[Category: U4 snrna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:45:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:16:59 2008''