1e9l: Difference between revisions

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[[Image:1e9l.jpg|left|200px]]
{{Seed}}
[[Image:1e9l.png|left|200px]]


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{{STRUCTURE_1e9l|  PDB=1e9l  |  SCENE=  }}  
{{STRUCTURE_1e9l|  PDB=1e9l  |  SCENE=  }}  


'''THE CRYSTAL STRUCTURE OF NOVEL MAMMALIAN LECTIN YM1 SUGGESTS A SACCHARIDE BINDING SITE'''
===THE CRYSTAL STRUCTURE OF NOVEL MAMMALIAN LECTIN YM1 SUGGESTS A SACCHARIDE BINDING SITE===




==Overview==
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Ym1, a secretory protein synthesized by activated murine peritoneal macrophages, is a novel mammalian lectin with a binding specificity to GlcN. Lectins are responsible for carbohydrate recognition and for mediating cell-cell and cell-extracellular matrix interactions in microbes, plants, and animals. Glycosaminoglycan heparin/heparan sulfate binding ability was also detected in Ym1. We report here the three-dimensional structure of Ym1 at 2.5-A resolution by x-ray crystallography. The crystal structure of Ym1 consists of two globular domains, a beta/alpha triose-phosphate isomerase barrel domain and a small alpha + beta folding domain. A notable electron density of sugar is detected in the Ym1 crystal structure. The saccharide is located inside the triose-phosphate isomerase domain at the COOH terminal end of the beta-strands. Both hydrophilic and hydrophobic interactions are noted in the sugar-binding site in Ym1. Despite the fact that Ym1 is not a chitinase, structurally, Ym1 shares significant homology with chitinase A of Serratia marcescens. Ym1 and chitinase A have a similar carbohydrate binding cleft. This study provides new structure information, which will lead to better understanding of the biological significance of Ym1 and its putative gene members.
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{{ABSTRACT_PUBMED_11278670}}


==About this Structure==
==About this Structure==
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[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Secretory]]
[[Category: Secretory]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:50:13 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:22:09 2008''

Revision as of 21:22, 30 June 2008

File:1e9l.png

Template:STRUCTURE 1e9l

THE CRYSTAL STRUCTURE OF NOVEL MAMMALIAN LECTIN YM1 SUGGESTS A SACCHARIDE BINDING SITE

Template:ABSTRACT PUBMED 11278670

About this Structure

1E9L is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of a novel mammalian lectin, Ym1, suggests a saccharide binding site., Sun YJ, Chang NC, Hung SI, Chang AC, Chou CC, Hsiao CD, J Biol Chem. 2001 May 18;276(20):17507-14. Epub 2001 Feb 15. PMID:11278670

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