1ed5: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1ed5.gif|left|200px]]
{{Seed}}
[[Image:1ed5.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ed5|  PDB=1ed5  |  SCENE=  }}  
{{STRUCTURE_1ed5|  PDB=1ed5  |  SCENE=  }}  


'''BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH NNA(H4B FREE)'''
===BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH NNA(H4B FREE)===




==Overview==
<!--  
Nitric oxide is generated under normal and pathophysiological conditions by three distinct isoforms of nitric oxide synthase (NOS). A small-molecule inhibitor of NOS (3-Br-7-nitroindazole, 7-NIBr) is profoundly neuroprotective in mouse models of stroke and Parkinson's disease. We report the crystal structure of the catalytic heme domain of endothelial NOS complexed with 7-NIBr at 1.65 A resolution. Critical to the binding of 7-NIBr at the substrate site is the adoption by eNOS of an altered conformation, in which a key glutamate residue swings out toward one of the heme propionate groups. Perturbation of the heme propionate ensues and eliminates the cofactor tetrahydrobiopterin-heme interaction. We also present three crystal structures that reveal how alterations at the substrate site facilitate 7-NIBr and structurally dissimilar ligands to occupy the cofactor site.
The line below this paragraph, {{ABSTRACT_PUBMED_11695891}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11695891 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_11695891}}


==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Heme protein]]
[[Category: Heme protein]]
[[Category: Nitric oxide synthase]]
[[Category: Nitric oxide synthase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:57:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:30:59 2008''

Revision as of 21:31, 30 June 2008

File:1ed5.png

Template:STRUCTURE 1ed5

BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH NNA(H4B FREE)

Template:ABSTRACT PUBMED 11695891

About this Structure

1ED5 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism., Raman CS, Li H, Martasek P, Southan G, Masters BS, Poulos TL, Biochemistry. 2001 Nov 13;40(45):13448-55. PMID:11695891

Page seeded by OCA on Tue Jul 1 00:30:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1ed5&oldid=591741"