1edq: Difference between revisions

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[[Image:1edq.gif|left|200px]]
{{Seed}}
[[Image:1edq.png|left|200px]]


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{{STRUCTURE_1edq|  PDB=1edq  |  SCENE=  }}  
{{STRUCTURE_1edq|  PDB=1edq  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF CHITINASE A FROM S. MARCESCENS AT 1.55 ANGSTROMS'''
===CRYSTAL STRUCTURE OF CHITINASE A FROM S. MARCESCENS AT 1.55 ANGSTROMS===




==Overview==
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The purification scheme of chitinase A (ChiA) from S. marcescens has been extensively revised. The pure enzyme crystallizes readily under new crystallization conditions. The ChiA crystal structure has been refined to 1.55 A resolution and the crystal structure of ChiA co-crystallized with the inhibitor allosamidin has been refined to 1.9 A resolution. Allosamidin is located in the deep active-site tunnel of ChiA and interacts with three important residues: Glu315, the proton donor of the catalysis, Asp313, which adopts two conformations in the native structure but is oriented towards Glu315 in the inhibitor complex, and Tyr390, which lies opposite Glu315 in the active-site tunnel.
The line below this paragraph, {{ABSTRACT_PUBMED_12554965}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12554965}}


==About this Structure==
==About this Structure==
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[[Category: Papanikolau, Y.]]
[[Category: Papanikolau, Y.]]
[[Category: Petratos, K.]]
[[Category: Petratos, K.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:58:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:32:29 2008''

Revision as of 21:32, 30 June 2008

File:1edq.png

Template:STRUCTURE 1edq

CRYSTAL STRUCTURE OF CHITINASE A FROM S. MARCESCENS AT 1.55 ANGSTROMS

Template:ABSTRACT PUBMED 12554965

About this Structure

1EDQ is a Single protein structure of sequence from Serratia marcescens. Full crystallographic information is available from OCA.

Reference

De novo purification scheme and crystallization conditions yield high-resolution structures of chitinase A and its complex with the inhibitor allosamidin., Papanikolau Y, Tavlas G, Vorgias CE, Petratos K, Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):400-3. Epub 2003, Jan 23. PMID:12554965

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