1ef1: Difference between revisions

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~~'''~~CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX~~'''~~

===CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX===

~~==Overview==~~

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The ~~ezrin-radixin-moesin (ERM) protein family link actin filaments of cell surface structures to the plasma membrane~~, ~~using a C-terminal F-actin binding segment and an N-terminal FERM domain~~, ~~a common membrane binding module. ERM proteins are regulated by an intramolecular association of~~ the ~~FERM and C-terminal tail domains that masks their binding sites. The crystal structure of a dormant moesin FERM/tail complex reveals that~~ the ~~FERM domain has three compact lobes including an integrated PTB~~/PH/ ~~EVH1 fold, with the C-terminal segment bound as an extended peptide masking a large surface of the FERM domain~~. ~~This extended binding mode suggests a novel mechanism for how different signals could produce varying levels of activation~~. ~~Sequence conservation suggests a similar regulation of~~ the ~~tumor suppressor merlin~~.

The line below this paragraph, {{ABSTRACT_PUBMED_10847681}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10847681 is the PubMed ID number.

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==About this Structure==

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[[Category: Membrane]]

[[Category: Tail domain]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 15~~:01:02 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:35:54 2008''

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-[[Image:1ef1.gif|left|200px]]
+{{Seed}}
+[[Image:1ef1.png|left|200px]]
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 {{STRUCTURE_1ef1|  PDB=1ef1  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX'''
+===CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX===
-==Overview==
+<!--
-The ezrin-radixin-moesin (ERM) protein family link actin filaments of cell surface structures to the plasma membrane, using a C-terminal F-actin binding segment and an N-terminal FERM domain, a common membrane binding module. ERM proteins are regulated by an intramolecular association of the FERM and C-terminal tail domains that masks their binding sites. The crystal structure of a dormant moesin FERM/tail complex reveals that the FERM domain has three compact lobes including an integrated PTB/PH/ EVH1 fold, with the C-terminal segment bound as an extended peptide masking a large surface of the FERM domain. This extended binding mode suggests a novel mechanism for how different signals could produce varying levels of activation. Sequence conservation suggests a similar regulation of the tumor suppressor merlin.
+The line below this paragraph, {{ABSTRACT_PUBMED_10847681}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10847681 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10847681}}
 ==About this Structure==
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 [[Category: Membrane]]
 [[Category: Tail domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:01:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:35:54 2008''