1efs: Difference between revisions

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[[Image:1efs.gif|left|200px]]
{{Seed}}
[[Image:1efs.png|left|200px]]


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{{STRUCTURE_1efs|  PDB=1efs  |  SCENE=  }}  
{{STRUCTURE_1efs|  PDB=1efs  |  SCENE=  }}  


'''CONFORMATION OF A DNA-RNA HYBRID'''
===CONFORMATION OF A DNA-RNA HYBRID===




==Overview==
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RNA--DNA hybrid duplexes are involved in transcription, replication and reverse transcription of nucleic acids. Information on such duplexes may shed some light on the mechanism of these processes. For this purpose, the influence of base composition on the structure of a polypyrimidine--polypurine RNA--DNA duplex r(cucuccuucucuu). d(GAGAGGAAGAGAA) has been studied using 1H, 31P and 13C NMR experiments, molecular modeling (JUMNA program) and NOE back-calculation methods. The resulting structure of the 13-mer hybrid duplex shows that the RNA strand is in the expected A-type conformation while the DNA strand is in a very flexible conformation. In the DNA strand, the desoxyribose sugars retain the C2'-endo B-type conformation. The duplex helical parameters (such as inclination, twist and displacement of the bases) are close to the A-type conformation. No bending was observed for the global axis curvature. The major groove width is close to the B-form value and the minor groove width is intermediate between standard values for A and B-forms. These results are in favour of the independence of minor groove size (where RNase H interacts) and the base composition of the hybrid duplexes.
The line below this paragraph, {{ABSTRACT_PUBMED_11311717}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11311717 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11311717}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EFS OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EFS OCA].  


==Reference==
==Reference==
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[[Category: Larue, V.]]
[[Category: Larue, V.]]
[[Category: Rna-dna hybrid duplex]]
[[Category: Rna-dna hybrid duplex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:02:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:37:46 2008''

Revision as of 21:37, 30 June 2008

File:1efs.png

Template:STRUCTURE 1efs

CONFORMATION OF A DNA-RNA HYBRID

Template:ABSTRACT PUBMED 11311717

About this Structure

Full experimental information is available from OCA.

Reference

Solution conformation of an RNA--DNA hybrid duplex containing a pyrimidine RNA strand and a purine DNA strand., Hantz E, Larue V, Ladam P, Le Moyec L, Gouyette C, Huynh Dinh T, Int J Biol Macromol. 2001 Apr 12;28(4):273-84. PMID:11311717

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