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| [[Image:1ejf.gif|left|200px]] | | {{Seed}} |
| | [[Image:1ejf.png|left|200px]] |
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| {{STRUCTURE_1ejf| PDB=1ejf | SCENE= }} | | {{STRUCTURE_1ejf| PDB=1ejf | SCENE= }} |
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| '''CRYSTAL STRUCTURE OF THE HUMAN CO-CHAPERONE P23'''
| | ===CRYSTAL STRUCTURE OF THE HUMAN CO-CHAPERONE P23=== |
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| ==Overview==
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| p23 is a co-chaperone for the heat shock protein, hsp90. This protein binds hsp90 and participates in the folding of a number of cell regulatory proteins, but its activities are still unclear. We have solved a crystal structure of human p23 lacking 35 residues at the COOH terminus. The structure reveals a disulfide-linked dimer with each subunit containing eight beta-strands in a compact antiparallel beta-sandwich fold. In solution, however, p23 is primarily monomeric and the dimer appears to be a minor component. Conserved residues are clustered on one face of the monomer and define a putative surface region and binding pocket for interaction(s) with hsp90 or protein substrates. p23 contains a COOH-terminal tail that is apparently less structured and is unresolved in the crystal structure. This tail is not needed for the binding of p23 to hsp90 or to complexes with the progesterone receptor. However, the tail is necessary for optimum active chaperoning of the progesterone receptor, as well as the passive chaperoning activity of p23 in assays measuring inhibition of heat-induced protein aggregation.
| | The line below this paragraph, {{ABSTRACT_PUBMED_10811660}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10811660 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_10811660}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Chaperone]] | | [[Category: Chaperone]] |
| [[Category: Co-chaperone]] | | [[Category: Co-chaperone]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:10:35 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:50:35 2008'' |
