1em2: Difference between revisions

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[[Image:1em2.~~jpg~~|left|200px]]

[[Image:1em2.png|left|200px]]

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~~'''~~STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64~~'''~~

===STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64===

~~==Overview==~~

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The ~~steroidogenic acute regulatory protein (StAR) regulates acute steroidogenesis in~~ the ~~adrenal cortex and gonads by promoting the translocation of cholesterol~~ to the ~~mitochondrial inner membrane where the first step in steriod biosynthesis is catalyzed. StAR-related lipid transfer~~ (START) domains occur in proteins involved in lipid transport and metabolism, signal transduction, and transcriptional regulation. The 2.2 A resolution crystal structure of the START domain of human MLN64 reported here reveals an alpha/~~beta fold built around a U-shaped incomplete beta-barrel~~. ~~The interior of the protein encompasses a 26 x 12 x 11 A hydrophobic tunnel that is large enough to bind a single cholesterol molecule~~. ~~The StAR and MLN64 START domains bind 1 mole of 14C cholesterol per mole of protein in vitro. Based on the START domain structure and cholesterol binding stoichiometry~~, it is ~~proposed that StAR acts by shuttling cholesterol molecules one at a time through the intermembrane space of~~ the ~~mitochondrion~~.

The line below this paragraph, {{ABSTRACT_PUBMED_10802740}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10802740 is the PubMed ID number.

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==About this Structure==

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[[Category: Tsujishita, Y.]]

[[Category: Beta barrel]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 15~~:15:58 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:58:06 2008''

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-[[Image:1em2.jpg|left|200px]]
+{{Seed}}
+[[Image:1em2.png|left|200px]]
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 {{STRUCTURE_1em2|  PDB=1em2  |  SCENE=  }}
-'''STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64'''
+===STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64===
-==Overview==
+<!--
-The steroidogenic acute regulatory protein (StAR) regulates acute steroidogenesis in the adrenal cortex and gonads by promoting the translocation of cholesterol to the mitochondrial inner membrane where the first step in steriod biosynthesis is catalyzed. StAR-related lipid transfer (START) domains occur in proteins involved in lipid transport and metabolism, signal transduction, and transcriptional regulation. The 2.2 A resolution crystal structure of the START domain of human MLN64 reported here reveals an alpha/beta fold built around a U-shaped incomplete beta-barrel. The interior of the protein encompasses a 26 x 12 x 11 A hydrophobic tunnel that is large enough to bind a single cholesterol molecule. The StAR and MLN64 START domains bind 1 mole of 14C cholesterol per mole of protein in vitro. Based on the START domain structure and cholesterol binding stoichiometry, it is proposed that StAR acts by shuttling cholesterol molecules one at a time through the intermembrane space of the mitochondrion.
+The line below this paragraph, {{ABSTRACT_PUBMED_10802740}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10802740 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10802740}}
 ==About this Structure==
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 [[Category: Tsujishita, Y.]]
 [[Category: Beta barrel]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:15:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:58:06 2008''