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[[Image:1emq.gif|left|200px]]
{{Seed}}
[[Image:1emq.png|left|200px]]


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{{STRUCTURE_1emq|  PDB=1emq  |  SCENE=  }}  
{{STRUCTURE_1emq|  PDB=1emq  |  SCENE=  }}  


'''NMR OBSERVATION OF T-TETRADS IN A PARALLEL STRANDED DNA QUADRUPLEX FORMED BY SACCHAROMYCES CEREVISIAE TELOMERE REPEATS'''
===NMR OBSERVATION OF T-TETRADS IN A PARALLEL STRANDED DNA QUADRUPLEX FORMED BY SACCHAROMYCES CEREVISIAE TELOMERE REPEATS===




==Overview==
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We report here the NMR structure of the DNA sequence d-TGGTGGC containing two repeats of Saccharomyces cerevisiae telomere DNA which is unique in that it has a single thymine in the repeat sequence and the number of Gs can vary from one to three. The structure is a novel quadruplex incor-porating T-tetrads formed by symmetrical pairing of four Ts via O4-H3 H-bonds in a plane. This is in contrast to the previous results on other telomeric sequences which contained more than one T in the repeat sequences and they were seen mostly in the flexible regions of the structures. We observed that the T4-tetrad was nicely accommodated in the center of the G-quadruplex, but it caused a small underwinding of the right handed helix. The T tetrad stacked well on the adjacent G3-tetrad, but poorly on the G5 tetrad. Likewise, T1 also formed a stable T-tetrad at the 5' end of the quadruplex. To our knowledge, this is the first report of T-tetrad formation in DNA structures. These observations are of significance from the points of view of both structural diversity and specific recognitions.
The line below this paragraph, {{ABSTRACT_PUBMED_10352174}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10352174 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10352174}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMQ OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMQ OCA].  


==Reference==
==Reference==
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[[Category: Telomere]]
[[Category: Telomere]]
[[Category: Yeast]]
[[Category: Yeast]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:17:14 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:59:46 2008''

Revision as of 21:59, 30 June 2008

File:1emq.png

Template:STRUCTURE 1emq

NMR OBSERVATION OF T-TETRADS IN A PARALLEL STRANDED DNA QUADRUPLEX FORMED BY SACCHAROMYCES CEREVISIAE TELOMERE REPEATS

Template:ABSTRACT PUBMED 10352174

About this Structure

Full experimental information is available from OCA.

Reference

NMR observation of T-tetrads in a parallel stranded DNA quadruplex formed by Saccharomyces cerevisiae telomere repeats., Patel PK, Hosur RV, Nucleic Acids Res. 1999 Jun 15;27(12):2457-64. PMID:10352174

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