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| {{STRUCTURE_1eo6| PDB=1eo6 | SCENE= }} | | {{STRUCTURE_1eo6| PDB=1eo6 | SCENE= }} |
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| '''CRYSTAL STRUCTURE OF GATE-16'''
| | ===CRYSTAL STRUCTURE OF GATE-16=== |
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| ==Overview==
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| The GATE-16 protein participates in intra-Golgi transport and can associate with the N-ethylmaleimide-sensitive fusion protein and with Golgi SNAREs. The yeast ortholog of GATE-16 is the autophagocytosis factor Aut7p. GATE-16 is also closely related to the GABA receptor-associated protein (GABARAP), which has been proposed to cluster neurotransmitter receptors by mediating interaction with the cytoskeleton, and to the light chain-3 subunit of the neuronal microtubule-associated protein complex. Here, we present the crystal structure of GATE-16 refined to 1.8 A resolution. GATE-16 contains a ubiquitin fold decorated by two additional N-terminal helices. Proteins with strong structural similarity but no detectable sequence homology to GATE-16 include Ras effectors that mediate diverse downstream functions, but each interacts with Ras by forming pseudo-continuous beta-sheets. The GATE-16 surface suggests that it binds its targets in a similar manner. Moreover, a second potential protein-protein interaction site on GATE-16 may explain the adapter activity observed for members of the GATE-16 family.
| | The line below this paragraph, {{ABSTRACT_PUBMED_10856287}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10856287 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_10856287}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Paz, Y.]] | | [[Category: Paz, Y.]] |
| [[Category: Ubiquitin fold]] | | [[Category: Ubiquitin fold]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:20:12 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:15:41 2008'' |
