1eoo: Difference between revisions

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[[Image:1eoo.gif|left|200px]]
{{Seed}}
[[Image:1eoo.png|left|200px]]


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{{STRUCTURE_1eoo|  PDB=1eoo  |  SCENE=  }}  
{{STRUCTURE_1eoo|  PDB=1eoo  |  SCENE=  }}  


'''ECORV BOUND TO COGNATE DNA'''
===ECORV BOUND TO COGNATE DNA===




==Overview==
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Two new high-resolution cocrystal structures of EcoRV endonuclease bound to DNA show that a large variation in DNA-bending angles is sampled in the ground state binary complex. Together with previous structures, these data reveal a contiguous series of protein conformational states delineating a specific trajectory for the induced-fit pathway. Rotation of the DNA-binding domains, together with movements of two symmetry-related helices binding in the minor groove, causes base unstacking at a key base-pair step and propagates structural changes that assemble the active sites. These structures suggest a complex mechanism for DNA bending that depends on forces generated by interacting protein segments, and on selective neutralization of phosphate charges along the inner face of the bent double helix.
The line below this paragraph, {{ABSTRACT_PUBMED_10801972}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10801972 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10801972}}


==About this Structure==
==About this Structure==
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[[Category: Induced fit]]
[[Category: Induced fit]]
[[Category: Protein-dna recognition]]
[[Category: Protein-dna recognition]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:21:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:20:48 2008''
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