1eq7: Difference between revisions

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[[Image:1eq7.gif|left|200px]]
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{{STRUCTURE_1eq7|  PDB=1eq7  |  SCENE=  }}  
{{STRUCTURE_1eq7|  PDB=1eq7  |  SCENE=  }}  


'''CORE STRUCTURE OF THE OUTER MEMBRANE LIPOPROTEIN FROM ESCHERICHIA COLI AT 1.9 ANGSTROM RESOLUTION'''
===CORE STRUCTURE OF THE OUTER MEMBRANE LIPOPROTEIN FROM ESCHERICHIA COLI AT 1.9 ANGSTROM RESOLUTION===




==Overview==
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The outer membrane lipoprotein of the Escherichia coli cell envelope has characteristic lipid modifications at an amino-terminal cysteine and can exist in a form bound covalently to the peptidoglycan through a carboxyl-terminal lysine. The 56-residue polypeptide moiety of the lipoprotein, designated Lpp-56, folds into a stable, trimeric helical structure in aqueous solution. The 1.9 A resolution crystal structure of Lpp-56 comprises a parallel three-stranded coiled coil including a novel alanine-zipper unit and two helix-capping motifs. The amino-terminal motif forms a hydrogen-bonding network anchoring an umbrella-shaped fold. The carboxyl-terminal motif uses puckering of the tyrosine side-chains as a unique docking arrangement in helix termination. The structure provides an explanation for assembly and insertion of the lipoprotein molecules into the outer membrane of gram-negative bacteria and suggests a molecular target for antibacterial drug discovery.
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{{ABSTRACT_PUBMED_10843861}}


==About this Structure==
==About this Structure==
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[[Category: Outer membrane]]
[[Category: Outer membrane]]
[[Category: Protein folding]]
[[Category: Protein folding]]
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Revision as of 22:39, 30 June 2008

File:1eq7.png

Template:STRUCTURE 1eq7

CORE STRUCTURE OF THE OUTER MEMBRANE LIPOPROTEIN FROM ESCHERICHIA COLI AT 1.9 ANGSTROM RESOLUTION

Template:ABSTRACT PUBMED 10843861

About this Structure

1EQ7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Core structure of the outer membrane lipoprotein from Escherichia coli at 1.9 A resolution., Shu W, Liu J, Ji H, Lu M, J Mol Biol. 2000 Jun 16;299(4):1101-12. PMID:10843861

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