1eqp: Difference between revisions

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[[Image:1eqp.~~gif~~|left|200px]]

[[Image:1eqp.png|left|200px]]

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~~'''~~EXO-B-(1,3)-GLUCANASE FROM CANDIDA ALBICANS~~'''~~

===EXO-B-(1,3)-GLUCANASE FROM CANDIDA ALBICANS===

~~==Overview==~~

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~~In some species of Candida the CUG codon is encoded as serine and not leucine. In the case of the exo~~-~~beta~~-1,~~3-glucanase from the pathogenic fungus C. albicans there are two such translational events~~, ~~one in~~ the ~~prepro-leader sequence and~~ the ~~other~~ at ~~residue 64~~. ~~Overexpression of active mature enzyme in a yeast host indicated that these two positions are tolerant to substitution~~. ~~By comparing the crystal structure of the recombinant protein with that of the native (presented here~~), it is ~~seen how either serine or leucine can be accommodated at position 64. Examination of~~ the ~~relatively few solved protein structures from C~~. ~~albicans indicates that other CUG encoded serines are also found at non~~-~~essential surface sites. However such codon usage is rare in C. albicans, in contrast to C. rugosa, with direct implications for respective recombinant protein production.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11112513}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11112513 is the PubMed ID number.

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==About this Structure==

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[[Category: Candida albican]]

[[Category: Exoglucanase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 15~~:25:07 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:43:40 2008''

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-[[Image:1eqp.gif|left|200px]]
+{{Seed}}
+[[Image:1eqp.png|left|200px]]
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 {{STRUCTURE_1eqp|  PDB=1eqp  |  SCENE=  }}
-'''EXO-B-(1,3)-GLUCANASE FROM CANDIDA ALBICANS'''
+===EXO-B-(1,3)-GLUCANASE FROM CANDIDA ALBICANS===
-==Overview==
+<!--
-In some species of Candida the CUG codon is encoded as serine and not leucine. In the case of the exo-beta-1,3-glucanase from the pathogenic fungus C. albicans there are two such translational events, one in the prepro-leader sequence and the other at residue 64. Overexpression of active mature enzyme in a yeast host indicated that these two positions are tolerant to substitution. By comparing the crystal structure of the recombinant protein with that of the native (presented here), it is seen how either serine or leucine can be accommodated at position 64. Examination of the relatively few solved protein structures from C. albicans indicates that other CUG encoded serines are also found at non-essential surface sites. However such codon usage is rare in C. albicans, in contrast to C. rugosa, with direct implications for respective recombinant protein production.
+The line below this paragraph, {{ABSTRACT_PUBMED_11112513}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11112513 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11112513}}
 ==About this Structure==
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 [[Category: Candida albican]]
 [[Category: Exoglucanase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:25:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 01:43:40 2008''