1f0j: Difference between revisions

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[[Image:1f0j.gif|left|200px]]
{{Seed}}
[[Image:1f0j.png|left|200px]]


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{{STRUCTURE_1f0j|  PDB=1f0j  |  SCENE=  }}  
{{STRUCTURE_1f0j|  PDB=1f0j  |  SCENE=  }}  


'''CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B'''
===CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B===




==Overview==
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Cyclic nucleotides are second messengers that are essential in vision, muscle contraction, neurotransmission, exocytosis, cell growth, and differentiation. These molecules are degraded by a family of enzymes known as phosphodiesterases, which serve a critical function by regulating the intracellular concentration of cyclic nucleotides. We have determined the three-dimensional structure of the catalytic domain of phosphodiesterase 4B2B to 1.77 angstrom resolution. The active site has been identified and contains a cluster of two metal atoms. The structure suggests the mechanism of action and basis for specificity and will provide a framework for structure-assisted drug design for members of the phosphodiesterase family.
The line below this paragraph, {{ABSTRACT_PUBMED_10846163}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10846163}}


==About this Structure==
==About this Structure==
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[[Category: Zhao, Y.]]
[[Category: Zhao, Y.]]
[[Category: Pde phosphodiesterase]]
[[Category: Pde phosphodiesterase]]
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