1f1z: Difference between revisions

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[[Image:1f1z.~~gif~~|left|200px]]

[[Image:1f1z.png|left|200px]]

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~~'''~~TNSA, a catalytic component of the TN7 transposition system~~'''~~

===TNSA, a catalytic component of the TN7 transposition system===

~~==Overview==~~

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~~Transposition requires a coordinated series of DNA breakage and joining reactions.~~ The ~~Tn7 transposase contains two proteins: TnsA, which carries out DNA breakage at the 5' ends of the transposon~~, ~~and TnsB~~, ~~which carries out breakage and joining at~~ the ~~3' ends of~~ the ~~transposon. TnsB is a member of the retroviral integrase superfamily whose hallmark is a conserved DDE motif. We report here the structure of TnsA~~ at 2.~~4 A resolution~~. ~~Surprisingly~~, the ~~TnsA fold is that of a type II restriction endonuclease~~. Thus, Tn7 transposition involves a collaboration between polypeptides, one containing a DDE motif and one that does not. This result indicates that the range of biological processes that utilize restriction enzyme-~~like folds also includes DNA transposition.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10911996}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10911996 is the PubMed ID number.

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==About this Structure==

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[[Category: May, E W.]]

[[Category: Restriction endonuclease fold]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 15~~:47:27 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:21:12 2008''

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-[[Image:1f1z.gif|left|200px]]
+{{Seed}}
+[[Image:1f1z.png|left|200px]]
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 {{STRUCTURE_1f1z|  PDB=1f1z  |  SCENE=  }}
-'''TNSA, a catalytic component of the TN7 transposition system'''
+===TNSA, a catalytic component of the TN7 transposition system===
-==Overview==
+<!--
-Transposition requires a coordinated series of DNA breakage and joining reactions. The Tn7 transposase contains two proteins: TnsA, which carries out DNA breakage at the 5' ends of the transposon, and TnsB, which carries out breakage and joining at the 3' ends of the transposon. TnsB is a member of the retroviral integrase superfamily whose hallmark is a conserved DDE motif. We report here the structure of TnsA at 2.4 A resolution. Surprisingly, the TnsA fold is that of a type II restriction endonuclease. Thus, Tn7 transposition involves a collaboration between polypeptides, one containing a DDE motif and one that does not. This result indicates that the range of biological processes that utilize restriction enzyme-like folds also includes DNA transposition.
+The line below this paragraph, {{ABSTRACT_PUBMED_10911996}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10911996 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10911996}}
 ==About this Structure==
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 [[Category: May, E W.]]
 [[Category: Restriction endonuclease fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:47:27 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 02:21:12 2008''