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| {{STRUCTURE_1f2n| PDB=1f2n | SCENE= }} | | {{STRUCTURE_1f2n| PDB=1f2n | SCENE= }} |
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| '''RICE YELLOW MOTTLE VIRUS'''
| | ===RICE YELLOW MOTTLE VIRUS=== |
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| ==Overview==
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| BACKGROUND: Rice yellow mottle virus (RYMV) is a major pathogen that dramatically reduces rice production in many African countries. RYMV belongs to the genus sobemovirus, one group of plant viruses with icosahedral capsids and single-stranded, positive-sense RNA genomes. RESULTS: The structure of RYMV was determined and refined to 2.8 A resolution by X-ray crystallography. The capsid contains 180 copies of the coat protein subunit arranged with T = 3 icosahedral symmetry. Each subunit adopts a jelly-roll beta sandwich fold. The RYMV capsid structure is similar to those of other sobemoviruses. When compared with these viruses, however, the betaA arm of the RYMV C subunit, which is a molecular switch that regulates quasi-equivalent subunit interactions, is swapped with the 2-fold-related betaA arm to a similar, noncovalent bonding environment. This exchange of identical structural elements across a symmetry axis is categorized as 3D domain swapping and produces long-range interactions throughout the icosahedral surface lattice. Biochemical analysis supports the notion that 3D domain swapping increases the stability of RYMV. CONCLUSIONS: The quasi-equivalent interactions between the RYMV proteins are regulated by the N-terminal ordered residues of the betaA arm, which functions as a molecular switch. Comparative analysis suggests that this molecular switch can also modulate the stability of the viral capsids.
| | The line below this paragraph, {{ABSTRACT_PUBMED_11080631}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11080631 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_11080631}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Plant virus]] | | [[Category: Plant virus]] |
| [[Category: X-ray diffraction]] | | [[Category: X-ray diffraction]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:48:59 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:24:56 2008'' |
