1f2q: Difference between revisions

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[[Image:1f2q.jpg|left|200px]]
{{Seed}}
[[Image:1f2q.png|left|200px]]


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{{STRUCTURE_1f2q|  PDB=1f2q  |  SCENE=  }}  
{{STRUCTURE_1f2q|  PDB=1f2q  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE HUMAN HIGH-AFFINITY IGE RECEPTOR'''
===CRYSTAL STRUCTURE OF THE HUMAN HIGH-AFFINITY IGE RECEPTOR===




==Overview==
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Allergic responses result from the activation of mast cells by the human high-affinity IgE receptor. IgE-mediated allergic reactions may develop to a variety of environmental compounds, but the initiation of a response requires the binding of IgE to its high-affinity receptor. We have solved the X-ray crystal structure of the antibody-binding domains of the human IgE receptor at 2.4 A resolution. The structure reveals a highly bent arrangement of immunoglobulin domains that form an extended convex surface of interaction with IgE. A prominent loop that confers specificity for IgE molecules extends from the receptor surface near an unusual arrangement of four exposed tryptophans. The crystal structure of the IgE receptor provides a foundation for the development of new therapeutic approaches to allergy treatment.
The line below this paragraph, {{ABSTRACT_PUBMED_9875849}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9875849 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9875849}}


==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
[[Category: Receptor]]
[[Category: Receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:49:13 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:26:08 2008''

Revision as of 23:26, 30 June 2008

File:1f2q.png

Template:STRUCTURE 1f2q

CRYSTAL STRUCTURE OF THE HUMAN HIGH-AFFINITY IGE RECEPTOR

Template:ABSTRACT PUBMED 9875849

About this Structure

1F2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human high-affinity IgE receptor., Garman SC, Kinet JP, Jardetzky TS, Cell. 1998 Dec 23;95(7):951-61. PMID:9875849

Page seeded by OCA on Tue Jul 1 02:26:08 2008

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