1f2v: Difference between revisions

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[[Image:1f2v.jpg|left|200px]]
{{Seed}}
[[Image:1f2v.png|left|200px]]


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{{STRUCTURE_1f2v|  PDB=1f2v  |  SCENE=  }}  
{{STRUCTURE_1f2v|  PDB=1f2v  |  SCENE=  }}  


'''CRYSTAL STRUCTURE ANALYSIS OF PRECORRIN-8X METHYLMUTASE OF AEROBIC VITAMIN B12 SYNTHESIS'''
===CRYSTAL STRUCTURE ANALYSIS OF PRECORRIN-8X METHYLMUTASE OF AEROBIC VITAMIN B12 SYNTHESIS===




==Overview==
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BACKGROUND: The crystal structure of precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12, provides evidence that the mechanism for methyl migration can plausibly be regarded as an allowed [1,5]-sigmatropic shift of a methyl group from C-11 to C-12 at the C ring of precorrin-8x to afford hydrogenobyrinic acid. RESULTS: The dimeric structure of CobH creates a set of shared active sites that readily discriminate between different tautomers of precorrin-8x and select a discrete tautomer for sigmatropic rearrangement. The active site contains a strictly conserved histidine residue close to the site of methyl migration in ring C of the substrate. CONCLUSION: Analysis of the structure with bound product suggests that the [1,5]-sigmatropic shift proceeds by protonation of the ring C nitrogen, leading to subsequent methyl migration.
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{{ABSTRACT_PUBMED_11470433}}


==About this Structure==
==About this Structure==
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[[Category: Alpha-beta wind]]
[[Category: Alpha-beta wind]]
[[Category: Doubly wound sheet]]
[[Category: Doubly wound sheet]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:49:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:27:51 2008''

Revision as of 23:28, 30 June 2008

File:1f2v.png

Template:STRUCTURE 1f2v

CRYSTAL STRUCTURE ANALYSIS OF PRECORRIN-8X METHYLMUTASE OF AEROBIC VITAMIN B12 SYNTHESIS

Template:ABSTRACT PUBMED 11470433

About this Structure

1F2V is a Single protein structure of sequence from Pseudomonas denitrificans. Full crystallographic information is available from OCA.

Reference

Crystal structure of precorrin-8x methyl mutase., Shipman LW, Li D, Roessner CA, Scott AI, Sacchettini JC, Structure. 2001 Jul 3;9(7):587-96. PMID:11470433

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