1f45: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1f45.gif|left|200px]]
{{Seed}}
[[Image:1f45.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1f45|  PDB=1f45  |  SCENE=  }}  
{{STRUCTURE_1f45|  PDB=1f45  |  SCENE=  }}  


'''HUMAN INTERLEUKIN-12'''
===HUMAN INTERLEUKIN-12===




==Overview==
<!--  
Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the crystal structures of monomeric human p40 at 2.5 A and the human p70 complex at 2.8 A resolution, which reveals that IL-12 is similar to class 1 cytokine-receptor complexes. They also include the first description of an N-terminal immunoglobulin-like domain, found on the p40 subunit. Several charged residues from p35 and p40 intercalate to form a unique interlocking topography, shown by mutagenesis to be critical for p70 formation. A central arginine residue from p35 projects into a deep pocket on p40, which may be an ideal target for a small molecule antagonist of IL-12 formation.
The line below this paragraph, {{ABSTRACT_PUBMED_10899108}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10899108 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10899108}}


==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: Interleukin]]
[[Category: Interleukin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:52:29 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:39:11 2008''
Retrieved from "https://proteopedia.org/1f45"