1f5y: Difference between revisions

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[[Image:1f5y.jpg|left|200px]]
{{Seed}}
[[Image:1f5y.png|left|200px]]


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{{STRUCTURE_1f5y|  PDB=1f5y  |  SCENE=  }}  
{{STRUCTURE_1f5y|  PDB=1f5y  |  SCENE=  }}  


'''NMR STRUCTURE OF A CONCATEMER OF THE FIRST AND SECOND LIGAND-BINDING MODULES OF THE HUMAN LDL RECEPTOR'''
===NMR STRUCTURE OF A CONCATEMER OF THE FIRST AND SECOND LIGAND-BINDING MODULES OF THE HUMAN LDL RECEPTOR===




==Overview==
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The ligand-binding domain of the human low-density lipoprotein receptor consists of seven modules, each of 40-45 residues. In the presence of calcium, these modules adopt a common polypeptide fold with three conserved disulfide bonds. A concatemer of the first and second modules (LB(1-2)) folds efficiently in the presence of calcium ions, forming the same disulfide connectivities as in the isolated modules. The three-dimensional structure of LB(1-2) has now been solved using two-dimensional 1H NMR spectroscopy and restrained molecular dynamics calculations. No intermodule nuclear Overhauser effects were observed, indicating the absence of persistent interaction between them. The near random-coil NH and H alpha chemical shifts and the low phi and psi angle order parameters of the four-residue linker suggest that it has considerable flexibility. The family of LB(1-2) structures superimposed well over LB1 or LB2, but not over both modules simultaneously. LB1 and LB2 have a similar pattern of calcium ligands, but the orientations of the indole rings of the tryptophan residues W23 and W66 differ, with the latter limiting solvent access to the calcium ion. From these studies, it appears that although most of the modules in the ligand-binding region of the receptor are joined by short segments, these linkers may impart considerable flexibility on this region.
The line below this paragraph, {{ABSTRACT_PUBMED_10933493}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10933493 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10933493}}


==About this Structure==
==About this Structure==
1F5Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F5Y OCA].  
1F5Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F5Y OCA].  


==Reference==
==Reference==
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[[Category: Beta hairpin]]
[[Category: Beta hairpin]]
[[Category: Calcium binding]]
[[Category: Calcium binding]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:56:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:45:14 2008''

Revision as of 23:45, 30 June 2008

File:1f5y.png

Template:STRUCTURE 1f5y

NMR STRUCTURE OF A CONCATEMER OF THE FIRST AND SECOND LIGAND-BINDING MODULES OF THE HUMAN LDL RECEPTOR

Template:ABSTRACT PUBMED 10933493

About this Structure

1F5Y is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure of a concatemer of the first and second ligand-binding modules of the human low-density lipoprotein receptor., Kurniawan ND, Atkins AR, Bieri S, Brown CJ, Brereton IM, Kroon PA, Smith R, Protein Sci. 2000 Jul;9(7):1282-93. PMID:10933493

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