1f8a: Difference between revisions

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[[Image:1f8a.gif|left|200px]]
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[[Image:1f8a.png|left|200px]]


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{{STRUCTURE_1f8a|  PDB=1f8a  |  SCENE=  }}  
{{STRUCTURE_1f8a|  PDB=1f8a  |  SCENE=  }}  


'''STRUCTURAL BASIS FOR THE PHOSPHOSERINE-PROLINE RECOGNITION BY GROUP IV WW DOMAINS'''
===STRUCTURAL BASIS FOR THE PHOSPHOSERINE-PROLINE RECOGNITION BY GROUP IV WW DOMAINS===




==Overview==
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Pin1 contains an N-terminal WW domain and a C-terminal peptidyl-prolyl cis-trans isomerase (PPIase) domain connected by a flexible linker. To address the energetic and structural basis for WW domain recognition of phosphoserine (P.Ser)/phosphothreonine (P. Thr)- proline containing proteins, we report the energetic and structural analysis of a Pin1-phosphopeptide complex. The X-ray crystal structure of Pin1 bound to a doubly phosphorylated peptide (Tyr-P.Ser-Pro-Thr-P.Ser-Pro-Ser) representing a heptad repeat of the RNA polymerase II large subunit's C-terminal domain (CTD), reveals the residues involved in the recognition of a single P.Ser side chain, the rings of two prolines, and the backbone of the CTD peptide. The side chains of neighboring Arg and Ser residues along with a backbone amide contribute to recognition of P.Ser. The lack of widespread conservation of the Arg and Ser residues responsible for P.Ser recognition in the WW domain family suggests that only a subset of WW domains can bind P.Ser-Pro in a similar fashion to that of Pin1.
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{{ABSTRACT_PUBMED_10932246}}


==About this Structure==
==About this Structure==
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[[Category: Phosphoserine binding]]
[[Category: Phosphoserine binding]]
[[Category: Ww domain]]
[[Category: Ww domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:01:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:51:27 2008''

Revision as of 23:51, 30 June 2008

File:1f8a.png

Template:STRUCTURE 1f8a

STRUCTURAL BASIS FOR THE PHOSPHOSERINE-PROLINE RECOGNITION BY GROUP IV WW DOMAINS

Template:ABSTRACT PUBMED 10932246

About this Structure

1F8A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for phosphoserine-proline recognition by group IV WW domains., Verdecia MA, Bowman ME, Lu KP, Hunter T, Noel JP, Nat Struct Biol. 2000 Aug;7(8):639-43. PMID:10932246

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