1f93: Difference between revisions

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[[Image:1f93.gif|left|200px]]
{{Seed}}
[[Image:1f93.png|left|200px]]


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{{STRUCTURE_1f93|  PDB=1f93  |  SCENE=  }}  
{{STRUCTURE_1f93|  PDB=1f93  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE DIMERIZATION DOMAIN OF HNF-1 ALPHA AND THE COACTIVATOR DCOH'''
===CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE DIMERIZATION DOMAIN OF HNF-1 ALPHA AND THE COACTIVATOR DCOH===




==Overview==
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Maturity-onset diabetes of the young type 3 (MODY3) results from mutations in the transcriptional activator hepatocyte nuclear factor-1alpha (HNF-1alpha). Several MODY3 mutations target the HNF-1alpha dimerization domain (HNF-p1), which binds the coactivator, dimerization cofactor of HNF-1 (DCoH). To define the mechanism of coactivator recognition and the basis for the MODY3 phenotype, we determined the cocrystal structure of the DCoH-HNF-p1 complex and characterized biochemically the effects of MODY3 mutations in HNF-p1. The DCoH-HNF-p1 complex comprises a dimer of dimers in which HNF-p1 forms a unique four-helix bundle. Through rearrangements of interfacial side chains, a single, bifunctional interface in the DCoH dimer mediates both HNF-1alpha binding and formation of a competing, transcriptionally inactive DCoH homotetramer. Consistent with the structure, MODY3 mutations in HNF-p1 reduce activator function by two distinct mechanisms.
The line below this paragraph, {{ABSTRACT_PUBMED_10966642}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10966642}}


==About this Structure==
==About this Structure==
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[[Category: Four-helix bundle]]
[[Category: Four-helix bundle]]
[[Category: Transcriptional activator/coactivator complex]]
[[Category: Transcriptional activator/coactivator complex]]
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