1fb1: Difference between revisions

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[[Image:1fb1.jpg|left|200px]]
{{Seed}}
[[Image:1fb1.png|left|200px]]


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{{STRUCTURE_1fb1|  PDB=1fb1  |  SCENE=  }}  
{{STRUCTURE_1fb1|  PDB=1fb1  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HUMAN GTP CYCLOHYDROLASE I'''
===CRYSTAL STRUCTURE OF HUMAN GTP CYCLOHYDROLASE I===




==Overview==
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The crystal structure of recombinant human GTP cyclohydrolase I was solved by Patterson search methods by using the coordinates of the Escherichia coli enzyme as a model. The human as well as bacterial enzyme were shown to contain an essential zinc ion coordinated to a His side chain and two thiol groups in each active site of the homodecameric enzymes that had escaped detection during earlier studies of the E. coli enzyme. The zinc ion is proposed to generate a hydroxyl nucleophile for attack of imidazole ring carbon atom eight of the substrate, GTP. It may also be involved in the hydrolytic release of formate from the intermediate, 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-triphosphate, and in the consecutive Amadori rearrangement of the ribosyl moiety.
The line below this paragraph, {{ABSTRACT_PUBMED_11087827}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11087827 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11087827}}


==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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