1fb8: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1fb8.gif|left|200px]]
{{Seed}}
[[Image:1fb8.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fb8|  PDB=1fb8  |  SCENE=  }}  
{{STRUCTURE_1fb8|  PDB=1fb8  |  SCENE=  }}  


'''STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH'''
===STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH===




==Overview==
<!--  
Pleckstrin homology (PH) domains are protein modules of around 120 amino acids found in many proteins involved in cellular signaling. Certain PH domains drive signal-dependent membrane recruitment of their host proteins by binding strongly and specifically to lipid second messengers produced by agonist-stimulated phosphoinositide 3-kinases (PI 3-Ks). We describe X-ray crystal structures of two different PH domains bound to Ins(1,3,4,5)P4, the head group of the major PI 3-K product PtdIns(3,4,5)P3. One of these PH domains (from Grp1) is PtdIns(3,4,5)P3 specific, while the other (from DAPP1/PHISH) binds strongly to both PtdIns(3,4,5)P3 and its 5'-dephosphorylation product, PtdIns(3,4)P2. Comparison of the two structures provides an explanation for the distinct phosphoinositide specificities of the two PH domains and allows us to predict the 3-phosphoinositide selectivity of uncharacterized PH domains.
The line below this paragraph, {{ABSTRACT_PUBMED_10983984}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10983984 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10983984}}


==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Inositol tetrakisphosphate signal transduction protein]]
[[Category: Inositol tetrakisphosphate signal transduction protein]]
[[Category: Pleckstrin]]
[[Category: Pleckstrin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:07:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:59:17 2008''

Revision as of 23:59, 30 June 2008

File:1fb8.png

Template:STRUCTURE 1fb8

STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH

Template:ABSTRACT PUBMED 10983984

About this Structure

1FB8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains., Ferguson KM, Kavran JM, Sankaran VG, Fournier E, Isakoff SJ, Skolnik EY, Lemmon MA, Mol Cell. 2000 Aug;6(2):373-84. PMID:10983984

Page seeded by OCA on Tue Jul 1 02:59:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1fb8&oldid=596434"