1fbr: Difference between revisions

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[[Image:1fbr.gif|left|200px]]
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[[Image:1fbr.png|left|200px]]


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{{STRUCTURE_1fbr|  PDB=1fbr  |  SCENE=  }}  
{{STRUCTURE_1fbr|  PDB=1fbr  |  SCENE=  }}  


'''FOURTH AND FIFTH FIBRONECTIN TYPE I MODULE PAIR'''
===FOURTH AND FIFTH FIBRONECTIN TYPE I MODULE PAIR===




==Overview==
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The tertiary structure of the fourth and fifth type 1 module pair from the N terminus of human fibronectin, has been determined by two-dimensional homonuclear 1H nuclear magnetic resonance (NMR) spectroscopy. Comparison of each module fold with those of two other type 1 modules shows that the type 1 "consensus" structure is conserved in the pair. The modules connect end-to-end to form an elongated structure with a limited clockwise twist around the long axis, from N to C terminus. The short five residue linker sequence forms a tight loop and the relative orientation of the two modules is maintained by fixed and intimate hydrophobic contacts, dominated by a non-conserved tryptophan residue from the fourth type 1 module. The protein binds specifically to fibrin in an ELISA and surface accessible residues that may be involved in this and other protein interactions can be identified. The structure provides an insight into how chains of type 1 modules may link up in intact fibronectin.
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(as it appears on PubMed at http://www.pubmed.gov), where 8308892 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8308892}}


==About this Structure==
==About this Structure==
1FBR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FBR OCA].  
1FBR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FBR OCA].  


==Reference==
==Reference==
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[[Category: Williams, M J.]]
[[Category: Williams, M J.]]
[[Category: Cell adhesion protein]]
[[Category: Cell adhesion protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:08:39 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:00:44 2008''

Revision as of 00:00, 1 July 2008

File:1fbr.png

Template:STRUCTURE 1fbr

FOURTH AND FIFTH FIBRONECTIN TYPE I MODULE PAIR

Template:ABSTRACT PUBMED 8308892

About this Structure

1FBR is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of a pair of fibronectin type 1 modules with fibrin binding activity., Williams MJ, Phan I, Harvey TS, Rostagno A, Gold LI, Campbell ID, J Mol Biol. 1994 Jan 28;235(4):1302-11. PMID:8308892

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