1fdo: Difference between revisions

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[[Image:1fdo.jpg|left|200px]]
{{Seed}}
[[Image:1fdo.png|left|200px]]


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{{STRUCTURE_1fdo|  PDB=1fdo  |  SCENE=  }}  
{{STRUCTURE_1fdo|  PDB=1fdo  |  SCENE=  }}  


'''OXIDIZED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI'''
===OXIDIZED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI===




==Overview==
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Formate dehydrogenase H from Escherichia coli contains selenocysteine (SeCys), molybdenum, two molybdopterin guanine dinucleotide (MGD) cofactors, and an Fe4S4 cluster at the active site and catalyzes the two-electron oxidation of formate to carbon dioxide. The crystal structures of the oxidized [Mo(VI), Fe4S4(ox)] form of formate dehydrogenase H (with and without bound inhibitor) and the reduced [Mo(IV), Fe4S4(red)] form have been determined, revealing a four-domain alphabeta structure with the molybdenum directly coordinated to selenium and both MGD cofactors. These structures suggest a reaction mechanism that directly involves SeCys140 and His141 in proton abstraction and the molybdenum, molybdopterin, Lys44, and the Fe4S4 cluster in electron transfer.
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{{ABSTRACT_PUBMED_9036855}}


==About this Structure==
==About this Structure==
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[[Category: Selenium]]
[[Category: Selenium]]
[[Category: Selenocysteine]]
[[Category: Selenocysteine]]
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Revision as of 00:05, 1 July 2008

File:1fdo.png

Template:STRUCTURE 1fdo

OXIDIZED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI

Template:ABSTRACT PUBMED 9036855

About this Structure

1FDO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster., Boyington JC, Gladyshev VN, Khangulov SV, Stadtman TC, Sun PD, Science. 1997 Feb 28;275(5304):1305-8. PMID:9036855

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