1fjj: Difference between revisions

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[[Image:1fjj.gif|left|200px]]
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[[Image:1fjj.png|left|200px]]


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{{STRUCTURE_1fjj|  PDB=1fjj  |  SCENE=  }}  
{{STRUCTURE_1fjj|  PDB=1fjj  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF E.COLI YBHB PROTEIN, A NEW MEMBER OF THE MAMMALIAN PEBP FAMILY'''
===CRYSTAL STRUCTURE OF E.COLI YBHB PROTEIN, A NEW MEMBER OF THE MAMMALIAN PEBP FAMILY===




==Overview==
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In rat and human cells, RKIP (previously known as PEBP) was characterized as an inhibitor of the MEK phosphorylation by Raf-1. In Escherichia coli, the genes ybhb and ybcl possibly encode two RKIP homologues while in the genomes of other bacteria and archaebacteria other homologous genes of RKIP have been found. The parallel between the cellular signaling mechanisms in eukaryotes and prokaryotes suggests that these bacterial proteins could be involved in the regulation of protein phosphorylation by kinases as well. We first showed that the proteins YBHB and YBCL were present in the cytoplasm and periplasm of E. coli, respectively, after which we determined their crystallographic structures. These structures verify that YBHB and YBCL belong to the same structural family as mammalian RKIP/PEBP proteins. The general fold and the anion binding site of these proteins are extremely well conserved between mammals and bacteria and suggest functional similarities. However, the bacterial proteins also exhibit some specific structural features, like a substrate binding pocket formed by the dimerization interface and the absence of cis peptide bonds. This structural variety should correspond to the recognition of multiple cellular partners.
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{{ABSTRACT_PUBMED_11439028}}


==About this Structure==
==About this Structure==
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[[Category: Zelwer, C.]]
[[Category: Zelwer, C.]]
[[Category: Pepb family]]
[[Category: Pepb family]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:21:56 2008''

Revision as of 00:21, 1 July 2008

File:1fjj.png

Template:STRUCTURE 1fjj

CRYSTAL STRUCTURE OF E.COLI YBHB PROTEIN, A NEW MEMBER OF THE MAMMALIAN PEBP FAMILY

Template:ABSTRACT PUBMED 11439028

About this Structure

1FJJ is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structures of YBHB and YBCL from Escherichia coli, two bacterial homologues to a Raf kinase inhibitor protein., Serre L, Pereira de Jesus K, Zelwer C, Bureaud N, Schoentgen F, Benedetti H, J Mol Biol. 2001 Jul 13;310(3):617-34. PMID:11439028

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