1fkm: Difference between revisions

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[[Image:1fkm.~~gif~~|left|200px]]

[[Image:1fkm.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF THE YPT/RAB-GAP DOMAIN OF GYP1P~~'''~~

===CRYSTAL STRUCTURE OF THE YPT/RAB-GAP DOMAIN OF GYP1P===

~~==Overview==~~

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~~We present the 1.9 A resolution crystal structure of the catalytic domain of Gyp1p~~, ~~a specific GTPase activating protein (GAP) for Ypt proteins~~, the yeast homologues of Rab proteins, which are involved in vesicular transport. Gyp1p is a member of a large family of eukaryotic proteins with shared sequence motifs. Previously, no structural information was available for any member of this class of proteins. The GAP domain of Gyp1p was found to ~~be fully alpha-helical. However,~~ the ~~observed fold does not superimpose with other alpha-helical GAPs~~ (e.g. ~~Ras- and Cdc42/Rho-GAP~~)~~. The conserved and catalytically crucial arginine residue, identified by mutational analysis~~, is ~~in a comparable position to~~ the ~~arginine finger in the Ras~~- ~~and Cdc42~~-GAPs, suggesting that Gyp1p utilizes an arginine finger in the GAP reaction, in analogy to Ras- and Cdc42-GAPs. A model for the interaction between Gyp1p and the Ypt protein satisfying biochemical data is given.

The line below this paragraph, {{ABSTRACT_PUBMED_11013213}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11013213 is the PubMed ID number.

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==About this Structure==

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[[Category: Vesicular trafficking]]

[[Category: Ypt/rab protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 16~~:26:19 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:24:37 2008''

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-[[Image:1fkm.gif|left|200px]]
+{{Seed}}
+[[Image:1fkm.png|left|200px]]
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 {{STRUCTURE_1fkm|  PDB=1fkm  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE YPT/RAB-GAP DOMAIN OF GYP1P'''
+===CRYSTAL STRUCTURE OF THE YPT/RAB-GAP DOMAIN OF GYP1P===
-==Overview==
+<!--
-We present the 1.9 A resolution crystal structure of the catalytic domain of Gyp1p, a specific GTPase activating protein (GAP) for Ypt proteins, the yeast homologues of Rab proteins, which are involved in vesicular transport. Gyp1p is a member of a large family of eukaryotic proteins with shared sequence motifs. Previously, no structural information was available for any member of this class of proteins. The GAP domain of Gyp1p was found to be fully alpha-helical. However, the observed fold does not superimpose with other alpha-helical GAPs (e.g. Ras- and Cdc42/Rho-GAP). The conserved and catalytically crucial arginine residue, identified by mutational analysis, is in a comparable position to the arginine finger in the Ras- and Cdc42-GAPs, suggesting that Gyp1p utilizes an arginine finger in the GAP reaction, in analogy to Ras- and Cdc42-GAPs. A model for the interaction between Gyp1p and the Ypt protein satisfying biochemical data is given.
+The line below this paragraph, {{ABSTRACT_PUBMED_11013213}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11013213 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11013213}}
 ==About this Structure==
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 [[Category: Vesicular trafficking]]
 [[Category: Ypt/rab protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:26:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:24:37 2008''