1flj: Difference between revisions

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[[Image:1flj.jpg|left|200px]]
{{Seed}}
[[Image:1flj.png|left|200px]]


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{{STRUCTURE_1flj|  PDB=1flj  |  SCENE=  }}  
{{STRUCTURE_1flj|  PDB=1flj  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF S-GLUTATHIOLATED CARBONIC ANHYDRASE III'''
===CRYSTAL STRUCTURE OF S-GLUTATHIOLATED CARBONIC ANHYDRASE III===




==Overview==
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S-Glutathiolation of carbonic anhydrase III (CAIII) occurs rapidly in hepatocytes under oxidative stress. The crystal structure of the S-glutathiolated CAIII from rat liver reveals covalent adducts on cysteines 183 and 188. Electrostatic charge and steric contacts at each modification site inversely correlate with the relative rates of reactivity of these cysteines toward glutathione (GSH). Diffuse electron density associated with the GSH adducts suggests a lack of preferred bonding interactions between CAIII and the glutathionyl moieties. Hence, the GSH adducts are available for binding by a protein capable of reducing this mixed disulfide. These properties are consistent with the participation of CAIII in the protection/recovery from the damaging effects of oxidative agents.
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{{ABSTRACT_PUBMED_11024467}}


==About this Structure==
==About this Structure==
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[[Category: S-glutathiolated]]
[[Category: S-glutathiolated]]
[[Category: S-glutathionylated]]
[[Category: S-glutathionylated]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:28:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:26:41 2008''

Revision as of 00:26, 1 July 2008

File:1flj.png

Template:STRUCTURE 1flj

CRYSTAL STRUCTURE OF S-GLUTATHIOLATED CARBONIC ANHYDRASE III

Template:ABSTRACT PUBMED 11024467

About this Structure

1FLJ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of S-glutathiolated carbonic anhydrase III., Mallis RJ, Poland BW, Chatterjee TK, Fisher RA, Darmawan S, Honzatko RB, Thomas JA, FEBS Lett. 2000 Oct 6;482(3):237-41. PMID:11024467

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