1fqi: Difference between revisions

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[[Image:1fqi.gif|left|200px]]
{{Seed}}
[[Image:1fqi.png|left|200px]]


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{{STRUCTURE_1fqi|  PDB=1fqi  |  SCENE=  }}  
{{STRUCTURE_1fqi|  PDB=1fqi  |  SCENE=  }}  


'''RGS9 RGS DOMAIN'''
===RGS9 RGS DOMAIN===




==Overview==
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A multitude of heptahelical receptors use heterotrimeric G proteins to transduce signals to specific effector target molecules. The G protein transducin, Gt, couples photon-activated rhodopsin with the effector cyclic GMP phosophodiesterase (PDE) in the vertebrate phototransduction cascade. The interactions of the Gt alpha-subunit (alpha(t)) with the inhibitory PDE gamma-subunit (PDEgamma) are central to effector activation, and also enhance visual recovery in cooperation with the GTPase-activating protein regulator of G-protein signalling (RGS)-9 (refs 1-3). Here we describe the crystal structure at 2.0 A of rod transducin alpha x GDP x AlF4- in complex with the effector molecule PDEgamma and the GTPase-activating protein RGS9. In addition, we present the independently solved crystal structures of the RGS9 RGS domain both alone and in complex with alpha(t/i1) x GDP x AlF4-. These structures reveal insights into effector activation, synergistic GTPase acceleration, RGS9 specificity and RGS activity. Effector binding to a nucleotide-dependent site on alpha(t) sequesters PDEgamma residues implicated in PDE inhibition, and potentiates recruitment of RGS9 for hydrolytic transition state stabilization and concomitant signal termination.
The line below this paragraph, {{ABSTRACT_PUBMED_11234020}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11234020 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11234020}}


==About this Structure==
==About this Structure==
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[[Category: Rgs9]]
[[Category: Rgs9]]
[[Category: Rod]]
[[Category: Rod]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:38:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:47:15 2008''

Revision as of 00:47, 1 July 2008

File:1fqi.png

Template:STRUCTURE 1fqi

RGS9 RGS DOMAIN

Template:ABSTRACT PUBMED 11234020

About this Structure

1FQI is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A., Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB, Nature. 2001 Feb 22;409(6823):1071-7. PMID:11234020

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